SynthesisEndocrine2020
Efficacy of thermal ablation in benign non-functioning solid thyroid nodule: A systematic review and meta-analysis.
Synthesis in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07178080 (Comparative Analysis of PIUR Imaging Technology for Volume Reduction Rate Measurement in Thyroid Nodule Ablations), which is not on this map. Cited by 73 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Analysis of PIUR Imaging Technology for Volume Reduction Rate Measurement in Thyroid Nodule Ablations
Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Ablative Technologies for Thyroid Nodules: A Health Technology Assessment.Ontario health technology assessment series · 2026Pooled it
- Efficacy of radiofrequency and laser thermal ablation in solving thyroid nodule-related symptoms and cosmetic concerns. A systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2022Pooled it
- Clinical Efficacy of Chinese and Western Medicine in the Treatment of Benign Thyroid Nodules: A Meta-Analysis.Contrast media & molecular imaging · 2022Pooled it
- Pooled it
- Multimodal Assessment of Tissue Response After Thyroid Radiofrequency Ablation: Clinical, Imaging, Histopathological and Molecular Insights.Journal of clinical medicine · 2026Article
- Morphologic, Immunohistochemical, and Molecular Features of Laser-Ablated Thyroid Nodules: Diagnostic Pitfalls and Differential Diagnosis with Thyroid Carcinoma.International journal of molecular sciences · 2026Article
- Patient-Reported Symptom Relief from Percutaneous Benign Thyroid Nodule Radiofrequency Ablation in Routine Clinical Care.AJNR. American journal of neuroradiology · 2026Article
- Comparative Efficacy of Two-Session Radiofrequency Ablation Versus Transarterial Embolization Followed by Radiofrequency Ablation for the Treatment of Large Benign Thyroid Nodules.International journal of endocrinology · 2026Article
- Improving radiofrequency ablation outcomes in large thyroid nodules: superiority of adjustable tip needles.Frontiers in endocrinology · 2026Observational
- Machine learning-based ultrasound radiomics for prediction of 6-month local thermal ablation response in benign thyroid nodules: a multicenter study.Frontiers in endocrinology · 2026Article
- The clinical utility of thermal ablation procedures in thyroid nodules: Latin American Thyroid Society (LATS) surgical affairs committee expert opinion. Part 2.Archives of endocrinology and metabolism · 2025Review
- Radiofrequency Ablation of Benign Thyroid Nodules: Preliminary Outcomes of an Endocrine Surgery Unit.Cureus · 2025Article
- Safety and Efficacy of Thermal Ablation for Benign Thyroid Nodules in Patients with or without Previous Thyroid Surgery.Radiology. Imaging cancer · 2025Article
- Radiofrequency Ablation for Thyroid Nodules (RATED Study)-Analysis of a Learning Curve and Predictors of Success.The Journal of clinical endocrinology and metabolism · 2025Observational
- Thermal field management improves patient-reported outcomes during ablation for papillary thyroid carcinoma: A retrospective cohort study.World journal of radiology · 2025Article
- Safety and Efficacy of Pressure-Enabled Thyroid Embolization: A Novel Approach for Symptomatic Thyroid Disease.Journal of the Endocrine Society · 2025Article
- Predictors of Initial Response of Thyroid Nodules Treated With RFA, a Multi-Endocrinology Centers Experience From the United States.Journal of the Endocrine Society · 2025Article
- Assessing the impact of malignant thyroid nodules on the efficacy of radiofrequency ablation: a single-center prospective study.Frontiers in endocrinology · 2025Article
- Minimally Invasive Thermal Ablation for Papillary Thyroid Microcarcinoma: Feasibility Analysis in Primary Healthcare Settings.International journal of endocrinology · 2025Review
- Laser ablation for spongiform thyroid nodules: identifying baseline nodule volume and energy to be delivered for successful treatment.Endocrine · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImage-guided thermal ablations are commonly used in the treatment of thyroid nodules. Radiofrequency ablation (RFA) and laser ablation are the most commonly used. Here we aimed to obtain solid evidence of the long-term efficacy of RFA and laser ablation in benign non-functioning solid thyroid nodules (BNFSTN).
methodsPubMed, CENTRAL, Scopus, and Web of Science were searched until March 2019. Studies reporting the effectiveness of RFA or laser ablation in patients with BNFSTN in terms of volume reduction rate (VRR), compressive symptoms and cosmetic concerns were included. Complications were also assessed.
resultsOut of 963 papers, 12 studies on RFA and 12 on laser ablation were included, assessing 1186 and 2009 BNFSTNs, respectively. Overall, VRR at 6, 12, 24, and 36 months was 60%, 66%, 62%, and 53%. VRR of RFA was 68%, 75%, and 87%, respectively. VRR of laser ablation was 48%, 52%, 45%, and 44%, respectively. Baseline volume of nodules undergone RFA was significantly smaller compared to laser ablation (20.1 ± 22.4 versus 24.6 ± 23.6 ml; p < 0.01). Nodules smaller than 30 ml obtained better outcomes than larger ones. A significant reduction in compressive symptoms and cosmetic concerns was found after RFA.
conclusionsThis meta-analysis showed that both RFA and laser ablation are able to obtain a significant volume reduction in BNFSTNs. A significant volume reduction is already evident at 6 months after thermal ablation and results are stable over the time.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.