Evidence map›Paper›PMID 31327120›Full record

ArticleMolecular biology reports2019

Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients.

Christopher Duma, Oleg Kopyov, Alex Kopyov, Mark Berman, Elliot Lander, Michael Elam, Michael Arata, David Weiland, Ruslana Cannell, Chad Caraway and 13 more

Registry-linked trialOpen access · hybridAbstract readClinical Trial, Phase I
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05667649 (Ph 1, Open-Label Safety Study of Escalating Doses of Intracerebroventricular Injections of Ex Vivo Expanded, Autologous ADSCs in Participants With Mild-Moderate AD Whose Treatment is Not Addressed Adequately by Available Therapy), which is not on this map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05667649 phase1recruitingnot on this mapstarted 2023, after this paper: background citation

Ph 1, Open-Label Safety Study of Escalating Doses of Intracerebroventricular Injections of Ex Vivo Expanded, Autologous ADSCs in Participants With Mild-Moderate AD Whose Treatment is Not Addressed Adequately by Available Therapy

TypeinterventionalSponsorRegeneration Biomedical, Inc.Ran2023 to 2026Enrolled18ConditionsAlzheimer DiseaseArmsRB-ADSC
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Christopher DumaNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA. cduma@brainandspineoc.com.ORCID http://orcid.org/0000-0003-3943-2030
Oleg KopyovNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Alex KopyovNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Mark BermanCell Surgical Network, Los Angeles, CA, USA.
Elliot LanderCell Surgical Network, Los Angeles, CA, USA.
Michael ElamCell Surgical Network, Los Angeles, CA, USA.
Michael ArataCell Surgical Network, Los Angeles, CA, USA.
David WeilandSchool of Medicine, University of California - Irvine, Irvine, CA, USA.
Ruslana CannellDepartment of Neurobiology, University of California - Irvine, Irvine, CA, USA.
Chad CarawayDepartment of Neurobiology, University of California - Irvine, Irvine, CA, USA.
Sean BermanCell Surgical Network, Los Angeles, CA, USA.
Kristin ScordNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Lian StemlerNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Karlyssa ChungNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Samuel KhoudariNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Rory McRoryNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Chace DumaNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Sawyer FarmerNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Anthony BravoNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Christian YassaNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Ami SanatharaNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Elisa SinghNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Benjamin RapaportNeurosurgery, Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Pancreatic Cancer Action Network · USUniversity of California, Irvine · USMaryland Brain, Spine + Pain · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have chosen to test the safety of human intracerebroventricular (ICV) brain injections of autologous non-genetically-modified adipose-derived stromal vascular fraction (ADSVF). In this IRB-approved trial, 24 patients received ICV ADSVF via an implanted reservoir between 5/22/14 and 5/22/17. Seven others were injected via their ventriculo-peritoneal shunts. Ten patients had Alzheimer's disease (AD), 6 had amyotrophic lateral sclerosis (ALS), 6 had progressive multiple sclerosis (MS-P), 6 had Parkinson's "Plus" (PD+), 1 had spinal cord injury, 1 had traumatic brain injury, and 1 had stroke. Median age was 74 (range 41-83). Injections were planned every 2-3 months. Thirty-one patients had 113 injections. Patients received SVF injection volumes of 3.5-20 cc (median:4 cc) containing 4.05 × 10

Indexed as

Adipose TissueAdultAgedAged, 80 and overFemaleHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansInfusions, IntraventricularMaleMesenchymal Stem Cell TransplantationMiddle AgedNeurodegenerative DiseasesTransplantation, AutologousTreatment OutcomeVentriculoperitoneal ShuntADSCALSAlzheimer’s diseaseAutologous stem cellsIntracerebroventricularMultiple sclerosisNeurodegenerative diseaseStem cellsStromal vascular fraction

Identifiers

PMID31327120
OpenAlexW2962677494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.