Evidence map›Paper›PMID 31327086›Full record

ArticleClinical rheumatology2019

Does symptomatic knee osteoarthritis increase the risk of all-cause mortality? Data from four international population-based longitudinal surveys of aging.

Zidan Yang, Guanghua Lei, Xiaoxiao Li, Yilun Wang, Zikun Xie, Xiurui Zhang, Yuchen He, Yilin Xiong, Tubao Yang

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zidan YangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Guanghua LeiHunan Key Laboratory of Joint Degeneration and Injury, Changsha, Hunan, China.
Xiaoxiao LiHunan Key Laboratory of Joint Degeneration and Injury, Changsha, Hunan, China.
Yilun WangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zikun XieDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiurui ZhangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuchen HeDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yilin XiongDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongyilin@csu.edu.cn.
Tubao YangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China. yangtb@csu.edu.cn.ORCID http://orcid.org/0000-0001-8762-1229

Funding

Clinical Scientific Research Foundation of Xiangya Hospital, Central South University 2015L03Fundamental Research Funds for the Central Universities of Central South University 2019zzts747Key Research and Development Program of Hunan Province 2018SK2070, 2018SK2073National Natural Science Foundation of China 81601941, 81772413, 81702207, 81702206Natural Science Foundation of Hunan Province 2017JJ3491, 2017JJ3492Postdoctoral Science Foundation of Central South University 182130Xiangya Clinical Big Data System Construction Project of Central South University 45Young Investigator Grant of Xiangya Hospital, Central South University 2016Q03, 2016Q06
6 · The paper itself

Abstract

objectiveThis study aimed at examining the association between symptomatic knee osteoarthritis and all-cause mortality based on four population-based longitudinal surveys.

methodData were retrieved from the English Longitudinal Study of Aging (ELSA), the Survey of Health, Aging and Retirement in Europe (SHARE), the Korean Longitudinal Study of Aging (KLoSA), and the Indonesian Family Life Survey (IFLS). The association between symptomatic knee osteoarthritis and all-cause mortality over the 8- to 12-year follow-up period was assessed using Cox-proportional hazard models.

resultsIn the entire sample of 59,522 participants (4823 with symptomatic knee osteoarthritis; 54,699 without symptomatic knee osteoarthritis [control group]; mean age: 61.8 years; female percentage: 55.3%), 8375 died (937 in the symptomatic knee osteoarthritis group, 7438 in the control group) during the follow-up period. Patients with symptomatic knee osteoarthritis had a higher risk of all-cause mortality than control group without adjusting for potential confounders in each survey, and the unadjusted hazard ratios (HRs) of all-cause mortality were 1.32 (95% confidence interval [CI] 1.18 to 1.47) in ELSA, 1.40 (95%CI 1.24 to 1.56) in SHARE, 1.25 (95%CI 1.06 to 1.47) in KLoSA, and 1.65 (95%CI 1.31 to 2.07) in IFLS. However, with adjustment of potential confounders, the corresponding HRs dropped to 1.07 (95%CI 0.94 to 1.20) in ELSA, 1.08 (95%CI 0.97 to 1.22) in SHARE, 0.91 (95%CI 0.77 to 1.08) in KLoSA, and 0.89 (95%CI 0.66 to 1.21) in IFLS, respectively.

conclusionsIn these four population-based longitudinal studies, no association between symptomatic knee osteoarthritis and increased risk of all-cause mortality was observed after adjusting for potential confounders. Key Points • This study evaluated the association between symptomatic knee OA and the risk of all-cause mortality among the participants retrieved from four large population-based longitudinal studies across the world. • No association between symptomatic knee osteoarthritis and increased risk of all-cause mortality was observed after considering potential confounders, and our findings were consistent with the results derived from four independent longitudinal studies. • The present study included four international population-based longitudinal studies, comprising both developed and developing areas, which allowed the findings to be interpreted under larger circumstance.

Indexed as

AgedAgingAsiaEuropeFemaleHumansLongitudinal StudiesMaleMiddle AgedOsteoarthritis, KneeKneeLongitudinal studiesMortalityOsteoarthritis

Identifiers

PMID31327086

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.