ArticleClinical oral investigations2020
Effect of various polymerization protocols on the cytotoxicity of conventional and self-adhesive resin-based luting cements.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- The Biocompatibility and Cellular Response of Geristore in Comparison With Different Glass Ionomer Materials on Human Gingival Fibroblast Cells: A Comparative Study on Deep Marginal Elevation.International journal of biomaterials · 2026Article
- Cytotoxicity of hydraulic cement dicalcium silicate mixture of eggshell calcium and rice husk silica on fibroblast cells.Journal of conservative dentistry and endodontics · 2025Article
- Effects of Different Self-Adhesive Resin Cements and Curing Through Zirconia on Gingival Fibroblasts.International dental journal · 2025Article
- A Novel Graphite Fluoride/Bioactive Glass-containing Orthodontic Primer with Antibacterial and Remineralization Properties: An In-vitro Study.The journal of adhesive dentistry · 2024Article
- Can Carbodiimide (EDC) and Chitosan Cross-linking Agents Effect the Longevity of Fiberglass Posts Luted with Different Types of Composite Cements to Root Dentin?The journal of adhesive dentistry · 2023Article
- In vitro cytotoxicity of different dental resin-cements on human cell lines.Journal of materials science. Materials in medicine · 2021Article
- Effect of the photoinitiator system on the polymerization of secondary methacrylamides of systematically varied structure for dental adhesive applications.Dental materials : official publication of the Academy of Dental Materials · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThis study evaluated the cytotoxicity of resin-based luting cements on fibroblast cells using different polymerization protocols. MATERIALS AND
methodsTwo conventional dual-polymerized (RelyX ARC, VariolinkN) and two self-adhesive resin cements (RelyX Unicem, Multilink Speed) specimens were polymerized using four different polymerization protocols: (a) photo-polymerization with direct light application, (b) photo-polymerization over ceramic and (c) resin nano-ceramic discs and (d) auto-polymerization. The specimens were then assigned to four groups to test cytotoxicity at 0, 1, 2 and 7 preincubation days (n = 5). MTT test was performed using NIH/3T3 fibroblast cells. Data were analysed using three- and one-way ANOVA. Multiple comparisons were made using Bonferroni post hoc test (p < 0.05).
resultsThe highest cytotoxic values were recorded at day 2 for conventional resin cements and at day 0 for self-adhesive resin cements. Self-adhesive resin cements showed the most cytotoxic effect at the second day, while conventional resin cements presented immediate cytotoxicity. Auto-polymerized resin specimens and especially Multilink Speed demonstrated the most cytotoxic effect regardless of the preincubation time. Cytotoxicity of cements tested reached the lowest level at day 7. Interposition of ceramic or nano-ceramic restorative material did not significantly affect the cytotoxicity of tested luting cements (p > 0.05).
conclusionsCytotoxicity of dual-polymerized resin cements was material-dependent and decreased gradually up to 7 days. Photo-polymerization plays an important role in reducing the cytotoxic effects. CLINICAL RELEVANCE: When luting ceramic or resin nano-ceramic restorations of which thickness does not exceed 2 mm, the level of cytotoxicity with the tested materials is not significant. Luting of restorative materials that do not allow for light transmission such as metal-fused porcelain, clinicians should be cautious in the use of dual-polymerized conventional resin cements as only auto-polymerization of resin cements takes place under such materials.
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