Evidence map›Paper›PMID 31327072›Full record

Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Genetic and lifestyle predictors of ischemic stroke severity and outcome.

Ivana Celap, Nora Nikolac Gabaj, Vida Demarin, Vanja Basic Kes, Ana-Maria Simundic

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ivana CelapDepartment of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia. ivana.celap@gmail.com.ORCID http://orcid.org/0000-0002-3982-5777
Nora Nikolac GabajDepartment of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Vida DemarinDepartment of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Vanja Basic KesDepartment of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Ana-Maria SimundicDepartment of Medical Laboratory Diagnostics, University Hospital Sveti Duh, Zagreb, Croatia.
University Hospital Centre Zagreb · HRSisters of Charity Hospital · HRUniversity of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDifferent models that include clinical variables and blood markers have been investigated to predict acute ischemic stroke treatment course and recovery.

aimThe aim of the study was to investigate associations between lipid levels, lifestyle factors, hemostatic (F5, F2, SERPINE1, F13A1, and FGB), and atherogenic (APOA5 and ACE) gene variants and acute ischemic stroke (AIS) severity. MATERIALS AND

methodsThis study included 250 patients with AIS in which F5, F2, SERPINE1, F13A1, FGB, APOA5, and ACE genotypes were determined. Total cholesterol (TC), high-density cholesterol, low-density cholesterol, and triglycerides concentrations were measured within 24 h of the AIS onset. Examination of the neurological deficit was done using National Institutes of Health Stroke Scale/Score (NIHSS).

resultsAPOA5 genotype [TC + CC] was more frequent (P = 0.026) in patients with the NIHSS score ≥ 21. Univariate regression analysis has shown that triglycerides (OR 0.55, 95% CI 0.34-0.91; P = 0.019), obesity (0.28, 95% CI 0.10-0.73; P = 0.010), age (OR 1.08, 95% CI 1.04-1.13; P < 0.001), and APOA5 genotype (TC + CC) (OR 2.40, 95% CI 1.10-5.25; P = 0.034) are significantly associated with a severe stroke. When all variables were included in model age (OR 1.06, 95% CI 1.01-1.11; P = 0.018), obesity (OR 0.25, 95% CI 0.08-0.77; P = 0.016) and APOA5 genotype (TC + CC) (OR 3.26, 95% CI 1.29-8.23; P = 0.012) remained significant for the risk of severe AIS.

conclusionAPOA5 genotype (TC + CC), age, and obesity could be used as prognostic risk factors for a very severe stroke (NIHSS ≥ 21).

Indexed as

Brain IschemiaObesitySeverity of Illness IndexStrokeAdultAgedAged, 80 and overAge FactorsApolipoprotein A-VCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsTriglyceridesAPOA5 protein, humanApolipoprotein A-VTriglyceridesAPOA5 variantRisk factorsStroke severityTriglycerides

Identifiers

PMID31327072
OpenAlexW2962892459

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.