Evidence map›Paper›PMID 31327031›Full record

ArticleHeart and vessels2020

Significant impact of left ventricular assist device models on the value of flow-mediated dilation: effects of LVAD on endothelial function.

Aya Watanabe, Eisuke Amiya, Masaru Hatano, Masafumi Watanabe, Atsuko Ozeki, Daisuke Nitta, Hisataka Maki, Yumiko Hosoya, Masaki Tsuji, Chie Bujo and 9 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04539093 (Assessment of Endothelial Function in Patients With Advanced Heart Failure Requiring Mechanical Circulatory Support), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04539093 completednot on this mapstarted 2022, after this paper: background citation

Assessment of Endothelial Function in Patients With Advanced Heart Failure Requiring Mechanical Circulatory Support

TypeobservationalSponsorMedical College of WisconsinRan2022 to 2022Enrolled1ConditionsHeart Failure With Reduced Ejection Fraction, Endothelial Dysfunction, LVADArmsExposure of interest - Use of left ventricular assist device (LVAD)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Vascular function in patients with advanced heart failure and continuous-flow or pulsatile ventricular assist devices.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  3. Review
  4. Assessment of ocular blood flow in continuous-flow ventricular assist device by laser speckle flowgraphy.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Aya WatanabeDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Eisuke AmiyaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. amiyae-tky@umin.ac.jp.ORCID http://orcid.org/0000-0003-2810-8040
Masaru HatanoDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masafumi WatanabeFirst Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Atsuko OzekiDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Daisuke NittaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hisataka MakiDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yumiko HosoyaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masaki TsujiDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Chie BujoDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Akihito SaitoDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Miyoko EndoDepartment of Organ Transplantation, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yukie KagamiDepartment of Organ Transplantation, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Mariko NemotoDepartment of Organ Transplantation, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kan NawataDepartment of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
Osamu KinoshitaDepartment of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
Mitsutoshi KimuraDepartment of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
Minoru OnoDepartment of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
Issei KomuroDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precise physiological changes associated with the use of left ventricular assist device (LVAD) are not well characterized. We examined the impact of changes in hemodynamic state using LVAD on endothelial function. We measured flow-mediated vasodilation (FMD) to evaluate endothelial vasodilator function of the brachial artery in 53 patients (dilated cardiomyopathy: 39, ischemic cardiomyopathy: 4, and others: 10) with an implanted LVAD (DuraHeart, EVAHEART, or HeartMate II). We found that FMD value in the HeartMateII LVAD group (9.3% ± 2.9%) was significantly higher than those in the other two groups (EVAHEART: 6.7% ± 2.8% and DuraHeart: 6.2% ± 4.0%). Other factors that affected the FMD value were age (r =  - 0.31, p = 0.026), Brinkman index (r =  - 0.30, p = 0.029); however, aortic opening, aortic regurgitation, and other hemodynamic parameters such as cardiac index or pulmonary capillary wedge pressure did not correlate with FMD. Multivariate analyses revealed that the difference among the LVAD models most significantly affected the FMD values after adjusting for age and smoking status (t = 2.6, p = 0.014). Event free survival rate of death and cerebral infarction was not significantly different according to the value of FMD. The difference among the LVAD groups most significantly affected the state of endothelial function and it had more impact than other clinical factors.

Indexed as

Heart-Assist DevicesVasodilationVentricular Function, LeftAdultBrachial ArteryEndothelium, VascularFemaleHeart FailureHumansMaleMiddle AgedProsthesis DesignProsthesis ImplantationRecovery of FunctionRisk FactorsTime FactorsFlow-mediated vasodilationInflammationLeft ventricular assist deviceVascular function

Identifiers

PMID31327031

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.