Evidence map›Paper›PMID 31326700›Full record

ArticleiScience2019

KLF2 in Myeloid Lineage Cells Regulates the Innate Immune Response during Skeletal Muscle Injury and Regeneration.

Palanikumar Manoharan, Taejeong Song, Tatiana L Radzyukevich, Sakthivel Sadayappan, Jerry B Lingrel, Judith A Heiny

Open access · goldAbstract read
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  3. Curcumin-activated Wnt5a pathway mediates CaJournal of cachexia, sarcopenia and muscle · 2024
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  7. Genome-Wide Analysis of theAnimals : an open access journal from MDPI · 2023
    Article
  8. Article
  9. Article
  10. Skeletal Muscle Regeneration in Cardiotoxin-Induced Muscle Injury Models.International journal of molecular sciences · 2022
    Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Palanikumar ManoharanDepartment of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA. Electronic address: manohapr@ucmail.uc.edu.
Taejeong SongDepartment of Internal Medicine, Heart, Lung and Vascular Institute, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Tatiana L RadzyukevichDepartment of Pharmacology and Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Sakthivel SadayappanDepartment of Internal Medicine, Heart, Lung and Vascular Institute, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Jerry B LingrelDepartment of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Judith A HeinyDepartment of Pharmacology and Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA. Electronic address: heinyja@ucmail.uc.edu.
University of Cincinnati Medical Center · USUniversity of Cincinnati · US

Funding

Isoform-specific roles of the Na,K-ATPase in skeletal muscleR01AR063710 · NIAMS · UNIVERSITY OF CINCINNATI · PI HEINY, JUDITH A, LINGREL, JERRY B · 2013 to 2017
$2.2M
NIAMS NIH HHS R01 AR063710
6 · The paper itself

Abstract

Skeletal muscle repair and regeneration after injury requires coordinated interactions between the innate immune system and the injured muscle. Myeloid cells predominate in these interactions. This study examined the role of KLF2, a zinc-finger transcription factor that regulates immune cell activation, in specifying myeloid cell functions during muscle regeneration. Loss of KLF2 in myeloid lineage cells (myeKlf2

Indexed as

Immune ResponseImmunologyMolecular PhysiologyPhysiology

Identifiers

PMID31326700
PMCPMC6652133
OpenAlexW2961887674

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.