Evidence map›Paper›PMID 31326666›Full record

ArticleActa biomaterialia2019

Mesh induced fibrosis: The protective role of T regulatory cells.

Amanda M Artsen, Matthew Rytel, Rui Liang, Gabrielle E King, Leslie Meyn, Steven D Abramowitch, Pamela A Moalli

Abstract read
In one paragraph

Article in Acta biomaterialia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
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  16. Article
  17. Losartan modifies mesh integration after abdominal wall repair: an experimental study.Hernia : the journal of hernias and abdominal wall surgery · 2022
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda M ArtsenMagee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences at Magee Womens Hospital, University of Pittsburgh, 204 Craft Avenue, Lab A320, Pittsburgh, PA 15213, USA. Electronic address: artsenam@upmc.edu.
Matthew RytelMagee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences at Magee Womens Hospital, University of Pittsburgh, 204 Craft Avenue, Lab A320, Pittsburgh, PA 15213, USA. Electronic address: matthew_rytel@brown.edu.
Rui LiangMagee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences at Magee Womens Hospital, University of Pittsburgh, 204 Craft Avenue, Lab A320, Pittsburgh, PA 15213, USA. Electronic address: liangr2@mwri.magee.edu.
Gabrielle E KingMagee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences at Magee Womens Hospital, University of Pittsburgh, Pittsburgh, PA, USA.
Leslie MeynMagee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences at Magee Womens Hospital, University of Pittsburgh, 204 Craft Avenue, Lab A320, Pittsburgh, PA 15213, USA. Electronic address: meynla@mwri.magee.edu.
Steven D AbramowitchDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Magee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences at Magee Womens Hospital, University of Pittsburgh, Pittsburgh, PA, USA.
Pamela A MoalliMagee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences at Magee Womens Hospital, University of Pittsburgh, 204 Craft Avenue, Lab A320, Pittsburgh, PA 15213, USA; Department of Bioengineering, University of Pittsburgh, 204 Craft Avenue, Lab A320, Pittsburgh, PA 15213, USA. Electronic address: moalpa@mail.magee.edu.

Funding

Porosity and tensioning: Critical factors to consider when choosing a prolapse meshR01HD083383 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ABRAMOWITCH, STEVEN D, MOALLI, PAMELA A. · 2016 to 2025
$5.5M
NICHD NIH HHS R01 HD083383
6 · The paper itself

Abstract

Polypropylene mesh is widely used in urogynecologic surgery, but complications rates (pain and exposure) approach 10%. Emerging evidence implicates the adaptive immune system in regulating the foreign body response to mesh, particularly regulatory T cells (T

Indexed as

Adaptive ImmunityAdultAgedBiopsyCollagenFemaleFibrosisHumansMiddle AgedPainSurgical MeshT-Lymphocytes, RegulatoryTransforming Growth Factor beta1Uterine ProlapseCollagenTransforming Growth Factor beta1FibrosisMidurethral slingPolypropylene meshProlapseT regulatory cells

Identifiers

PMID31326666
PMCPMC6717663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.