ArticleNeuroImage2019
Role of the inhibitory system in shaping the BOLD fMRI response.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Heterogeneity, Measurement, and Clinical Implications of Oxygenation, Cell Signaling, and Redox Biology in Glioblastoma and Adult Diffuse Gliomas, with Context from Other Brain Tumors.Antioxidants (Basel, Switzerland) · 2026Review
- Assessing chance in neuro-vascular interactions.NeuroImage · 2026Article
- Long-Term GABAergic Modulation of Brain Tissue Oxygenation and Electrophysiological Activity Following Neonatal Anesthesia Exposure.Advances in experimental medicine and biology · 2026Article
- Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex.Nature communications · 2023Article
- Brain Response to Interferential Current Compared with Alternating Current Stimulation.Brain sciences · 2023Article
- Electric Field Effects on Brain Activity: Implications for Epilepsy and Burst Suppression.Cells · 2023Article
- Article
- Brain Tissue Oxygen and BOLD fMRI Under Different Levels of Neuronal Activity.Advances in experimental medicine and biology · 2023Article
- Inferring excitation-inhibition dynamics using a maximum entropy model unifying brain structure and function.Network neuroscience (Cambridge, Mass.) · 2022Article
- Function and development of interneurons involved in brain tissue oxygen regulation.Frontiers in molecular neuroscience · 2022Review
- Brain tissue oxygen dynamics while mimicking the functional deficiency of interneurons.Frontiers in cellular neuroscience · 2022Article
- Early Development of the GABAergic System and the Associated Risks of Neonatal Anesthesia.International journal of molecular sciences · 2021Review
- Article
- The Contribution of Dysfunctional Chloride Channels to Neurovascular Deficiency and Neurodegeneration.Frontiers in pharmacology · 2021Article
- Normal Development of Local Neurovascular Interactions and the Diagnostic Value of Resting State Functional MRI in Neurovascular Deficiency Based on the Example of Neonatal Anesthesia Exposure.Frontiers in neurology · 2021Article
- EEG-fMRI Signal Coupling Is Modulated in Subjects With Mild Cognitive Impairment and Amyloid Deposition.Frontiers in aging neuroscience · 2021Article
- Effects of neonatal isoflurane anesthesia exposure on learning-specific and sensory systems in adults.Scientific reports · 2020Article
- Impact of anesthesia exposure in early development on learning and sensory functions.Developmental psychobiology · 2020Review
- Behavior and Regional Cortical BOLD Signal Fluctuations Are Altered in Adult Rabbits After Neonatal Volatile Anesthetic Exposure.Frontiers in neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The shape of the blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal can vary considerably even across structures of the same sensory pathway. Here, we characterized the temporal behavior of the stimulus-evoked BOLD response in the primary cortical and subcortical regions of the visual and somatosensory whisker systems in awake rabbits. Despite similar BOLD responses in the thalamic nuclei, considerable differences in shape and duration emerged between the sensory cortices. Whereas the BOLD response in the whisker barrel cortex (WBC) was non-adaptive, BOLD in the visual cortex (V1) showed adaptation similar to simultaneously-recorded LFP and single unit activity. Analysis of baseline neuronal activity revealed significantly lower firing rates in V1 vs. WBC. We hypothesized that these changes point to region-dependent differences in the inhibitory systems which shape the hemodynamic response in each structure. To test the effect of neuronal baseline level inhibition on the BOLD signal shape, we locally injected the GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.