Evidence map›Paper›PMID 31326533›Full record

ArticleNeurobiology of learning and memory2019

Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory.

Sarah M Reinhard, Maham Rais, Sonia Afroz, Yasmien Hanania, Kasim Pendi, Katherine Espinoza, Robert Rosenthal, Devin K Binder, Iryna M Ethell, Khaleel A Razak

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

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  9. EphB2 Signaling Is Implicated in Astrocyte-Mediated Parvalbumin Inhibitory Synapse Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sarah M ReinhardPsychology Department and Psychology Graduate Program, University of California, Riverside, CA 92521, USA.
Maham RaisDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA.
Sonia AfrozDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA.
Yasmien HananiaDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA.
Kasim PendiDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA.
Katherine EspinozaPsychology Department and Psychology Graduate Program, University of California, Riverside, CA 92521, USA; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA.
Robert RosenthalPsychology Department and Psychology Graduate Program, University of California, Riverside, CA 92521, USA.
Devin K BinderDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA; Neuroscience Graduate Program, University of California, Riverside, CA 92521, USA.
Iryna M EthellDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA; Neuroscience Graduate Program, University of California, Riverside, CA 92521, USA. Electronic address: iryna.ethell@medsch.ucr.edu.
Khaleel A RazakPsychology Department and Psychology Graduate Program, University of California, Riverside, CA 92521, USA; Neuroscience Graduate Program, University of California, Riverside, CA 92521, USA. Electronic address: Khaleel@ucr.edu.
University of California, Riverside · US

Funding

Neurophysiological and acute pharmacological studies in FXS patientsU54HD082008 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI HUBER, KIMBERLY M. · 2014 to 2019
$9.8M
EphB Signaling in Dendritic Spine Development and RemodelingR01MH067121 · NIMH · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ETHELL, IRYNA M · 2003 to 2017
$4.6M
NICHD NIH HHS U54 HD082008NIMH NIH HHS R01 MH067121
6 · The paper itself

Abstract

Fragile X Syndrome (FXS) is a leading cause of heritable intellectual disability and autism. Humans with FXS show anxiety, sensory hypersensitivity and impaired learning. The mechanisms of learning impairments can be studied in the mouse model of FXS, the Fmr1 KO mouse, using tone-associated fear memory paradigms. Our previous study reported impaired development of parvalbumin (PV) positive interneurons and perineuronal nets (PNN) in the auditory cortex of Fmr1 KO mice. A recent study suggested PNN dynamics in the auditory cortex following tone-shock association is necessary for fear expression. Together these data suggest that abnormal PNN regulation may underlie tone-fear association learning deficits in Fmr1 KO mice. We tested this hypothesis by quantifying PV and PNN expression in the amygdala, hippocampus and auditory cortex of Fmr1 KO mice following fear conditioning. We found impaired tone-associated memory formation in Fmr1 KO mice. This was paralleled by impaired learning-associated regulation of PNNs in the superficial layers of auditory cortex in Fmr1 KO mice. PV cell density decreased in the auditory cortex in response to fear conditioning in both WT and Fmr1 KO mice. Learning-induced increase of PV expression in the CA3 hippocampus was only observed in WT mice. We also found reduced PNN density in the amygdala and auditory cortex of Fmr1 KO mice in all conditions, as well as reduced PNN intensity in CA2 hippocampus. There was a positive correlation between tone-associated memory and PNN density in the amygdala and auditory cortex, consistent with a tone-association deficit. Altogether our studies suggest a link between impaired PV and PNN regulation within specific regions of the fear conditioning circuit and impaired tone memory formation in Fmr1 KO mice.

Indexed as

AmygdalaAnimalsAuditory CortexConditioning, ClassicalFearFragile X Messenger Ribonucleoprotein 1InterneuronsMaleMemoryMice, KnockoutNeural PathwaysNeuronsParvalbuminsFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1ParvalbuminsAuditory cortexFear conditioningFragile X syndromeLearning deficitsParvalbuminPerineuronal nets

Identifiers

PMID31326533
PMCPMC7519848
OpenAlexW2961388961

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.