ArticleProgress in neuro-psychopharmacology & biological psychiatry2019
Examination of pain threshold and neuropeptides in patients with acute suicide risk.
Article in Progress in neuro-psychopharmacology & biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Increased C-reactive protein concentration and suicidal behavior in people with psychiatric disorders: A systematic review and meta-analysis.Acta psychiatrica Scandinavica · 2021Pooled it
- Serum Endogenous Opioid Levels are Associated with Self-Injury Severity in Adolescents with Non-Suicidal Self-Injury and Comorbid Depression.Neuroscience bulletin · 2026Article
- Association of Pain Intensity and Sensitivity with Childhood Trauma in Adolescents with Depressive Disorder: A Multicenter Study.Psychology research and behavior management · 2026Article
- Psychological pain tolerance mediates the association between physical pain sensitivity and suicidal ideation: a cross-sectional study.BMC psychiatry · 2025Article
- Progesterone receptor distribution in the human hypothalamus and its association with suicide.Acta neuropathologica communications · 2024Article
- Association of Pain Intensity and Sensitivity with Suicidal Ideation in Adolescents with Depressive Disorder.Psychology research and behavior management · 2024Article
- Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug Targets.Current neuropharmacology · 2024Review
- Peripheral Markers of Suicidal Behavior: Current Findings and Clinical Implications.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Review
- Exploring Associations between C-Reactive Protein and Self-Reported Interoception in Major Depressive Disorder: A Bayesian Analysis.Brain sciences · 2023Article
- Review
- Neurotensin and Xenin Show Positive Correlations With Perceived Stress, Anxiety, Depressiveness and Eating Disorder Symptoms in Female Obese Patients.Frontiers in behavioral neuroscience · 2021Article
- Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
introductionOne of the main challenges in suicide prevention is the limited understanding of the biological mechanisms underlying suicide. Recent findings suggest impairments in pain processing in acutely suicidal patients. However, little is known about the biological factors that may drive these discrete physiological abnormalities. In this study, we examined plasma peptides involved in analgesic and inflammatory responses and physical pain threshold in acutely suicidal patients.
methodsThirty-seven depressed patients of both sexes hospitalized for severe suicidal ideation or a recent suicide attempt were characterized clinically including history of suicidal ideation and behavior. Psychological and physical pain, and pressure pain threshold was also measured. Plasma levels of β-endorphin, neurotensin, agouti-related protein (AgRP), C-reactive protein (CRP), adrenocorticotropic hormone (ACTH), and brain-derived neurotrophic factor (BDNF) were run in Milliplex multiplex assays.
resultsThe number of lifetime suicide attempts was positively correlated with β-endorphin (r = 0.702; p = 0.007), and neurotensin (r = 0.728, p = 0.007) plasma levels. Higher pain threshold was measured in the suicide attempt group as compared to the suicidal ideation group. Pain threshold was strongly and negatively associated with CRP plasma levels (r = -0.548; p < 0.001). In patients reporting chronic pain, lower AgRP levels and lower pain threshold were observed (t = 4.472; p = 0.001).
conclusionOur results suggest that abnormalities in the opioid and neurotensin systems may underlie the increase in pain threshold found in suicide attempters, and possibly risk for suicidal behavior. Targeting pain circuits and systems may provide therapeutic mechanisms for suicide prevention.
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