Evidence map›Paper›PMID 31326460›Full record

ArticleNeurochemistry international2019

Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS.

Lauren Kosten, Golam M I Chowdhury, Susana Mingote, Steven Staelens, Douglas L Rothman, Kevin L Behar, Stephen Rayport

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemistry international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Lauren KostenMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Golam M I ChowdhuryDepartment of Psychiatry, Magnetic Resonance Research Center, Yale University School of Medicine, USA.
Susana MingoteDepartment of Psychiatry, Columbia University, USA; Department of Molecular Therapeutics, NYS Psychiatric Institute, USA; Neuroscience, Advanced Science Research Center at the Graduate Center of the City University of New York, USA.
Steven StaelensMolecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.
Douglas L RothmanDepartment of Radiology & Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, USA.
Kevin L BeharDepartment of Psychiatry, Magnetic Resonance Research Center, Yale University School of Medicine, USA. Electronic address: Kevin.behar@yale.edu.
Stephen RayportDepartment of Psychiatry, Columbia University, USA; Department of Molecular Therapeutics, NYS Psychiatric Institute, USA. Electronic address: stephen.rayport@nyspi.columbia.edu.
Columbia University · USResonance Research (United States) · USUniversity of Antwerp · BEYale University · US

Funding

Targeting cotransmission for circuit-specific pharmacotherapyR01MH117128 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI RAYPORT, STEPHEN · 2018 to 2022
$2.9M
Therapeutic potential of GLS1 inhibition for the pharmacotherapy of schizophreniaR01MH087758 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RAYPORT, STEPHEN · 2010 to 2014
$1.8M
Validation of GABA MRS as a Biomarker of InhibitionR01MH109159 · NIMH · YALE UNIVERSITY · PI BEHAR, KEVIN L, ROTHMAN, DOUGLAS LYLE · 2016 to 2019
$1.7M
NIMH NIH HHS R01 MH087758NIMH NIH HHS R01 MH109159NIMH NIH HHS R01 MH117128
6 · The paper itself

Abstract

Glutaminase mediates the recycling of neurotransmitter glutamate, supporting most excitatory neurotransmission in the mammalian central nervous system. A constitutive heterozygous reduction in GLS1 engenders in mice a model of schizophrenia resilience and associated increases in Gln, reductions in Glu and activity-dependent attenuation of excitatory synaptic transmission. Hippocampal brain slices from GLS1 heterozygous mice metabolize less Gln to Glu. Whether glutaminase activity is diminished in the intact brain in GLS1 heterozygous mice has not been assessed, nor the regional impact. Moreover, it is not known whether pharmacological inhibition would mimic the genetic reduction. We addressed this using magnetic resonance spectroscopy to assess amino acid content and

Indexed as

Amino AcidsAnimalsAzolesBrainBrain ChemistryFemalegamma-Aminobutyric AcidGlutaminaseHeterozygoteHippocampusIsoindolesMaleMiceNerve Tissue ProteinsNuclear Magnetic Resonance, BiomolecularOrganoselenium CompoundsAmino AcidsAzolesebselengamma-Aminobutyric AcidGLS1 protein, mouseGlutaminaseIsoindolesNerve Tissue ProteinsOrganoselenium CompoundsFocused beam microwave irradiationGABAGlutamate-glutamine cyclingMagnetic resonance spectroscopySchizophrenia pharmacotherapy

Identifiers

PMID31326460
PMCPMC6941670
OpenAlexW2964142412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.