ArticleJournal of geriatric oncology2020
A comparison of three different approaches to defining frailty in older patients with multiple myeloma.
Article in Journal of geriatric oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Geriatric assessment in older patients with a hematologic malignancy: a systematic review.Haematologica · 2020Pooled it
- The concept of multidimensional frailty in geriatric oncology: a systematic scoping review.BMC geriatrics · 2025Article
- How First-Line Therapy is Changing in non-Transplant Eligible Multiple Myeloma Patients.Mediterranean journal of hematology and infectious diseases · 2025Review
- Selection determines therapeutic effects: a retrospective analysis of the application of different frailty tools in elderly patients with multiple myeloma.Discover oncology · 2024Article
- Review
- An objective assessment in newly diagnosed multiple myeloma to avoid treatment complications and strengthen therapy adherence.Haematologica · 2023Article
- The limited use of autologous hematopoietic stem cell transplant for fit older patients with multiple myeloma in India: a retrospective analysis.Journal of the Egyptian National Cancer Institute · 2022Article
- Decision-making factors for an autologous stem cell transplant for older adults with newly diagnosed multiple myeloma: A qualitative analysis.Frontiers in oncology · 2022Article
- Article
- Older adults with cancer and their caregivers - current landscape and future directions for clinical care.Nature reviews. Clinical oncology · 2020Review
- Older cancer patients and COVID-19 outbreak: Practical considerations and recommendations.Cancer medicine · 2020Review
- Risk and Response-Adapted Treatment in Multiple Myeloma.Cancers · 2020Review
- Defining the vulnerable patient with myeloma-a frailty position paper of the European Myeloma Network.Leukemia · 2020Article
- Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies.Journal of personalized medicine · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesAs the aging population grows, interest in applying the concept of frailty to older adults with cancer has increased. This study examines the prevalence of frailty in older patients with multiple myeloma using three frailty models.
methodsIn this secondary analysis of a prospective cohort study, 40 adults aged ≥65 with myeloma completed the Cancer and Aging Research Group geriatric assessment within three months of initial diagnosis. Geriatric assessment data was used to categorize patients' frailty status according to three indices: The International Myeloma Working Group (IMWG) Frailty Index, the Revised Myeloma Comorbidity Index (R-MCI), and the Carolina Frailty Index (CFI). Agreement between the indices was examined using Cohen's kappa.
resultsTwenty-eight patients were classified as frail by at least one of the models. However, only slight agreement exists on the classification of frailty among the indices, with little concordance among the models (Kappa 0.03-0.12). Only three patients were categorized as frail by all three models.
conclusionIn a cohort of 40 older adults with newly diagnosed multiple myeloma, three frailty indices have differing approaches to operationalizing frailty resulting, in different patients being categorized as frail. Little agreement existed between the models. Further studies are needed to explore the utility of these models in predicting treatment toxicity and prognosis.
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