ReviewSexual medicine reviews2019
Impact of Immune System Activation and Vascular Impairment on Male and Female Sexual Dysfunction.
Review in Sexual medicine reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Prevalence and associated factors of sexual dysfunction in female patients with immune thrombocytopenia: a longitudinal follow-up study.BMC women's health · 2026Article
- Erectile and Clitoral Dysfunction as Harbingers of Cardiovascular Disease: A Perspective.Medicina (Kaunas, Lithuania) · 2026Review
- Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in primary versus secondary premature ejaculation: a comparative study.Basic and clinical andrology · 2026Article
- Advances in immune-inflammatory interactions within the testicular-penile microenvironment of varicocele patients: molecular mechanisms underlying erectile dysfunction and spermatogenic impairment.Frontiers in endocrinology · 2026Review
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- Article
- Sexual Functioning and Depressive Symptoms in Levothyroxine-Treated Women with Postpartum Thyroiditis and Different Vitamin D Status.Nutrients · 2025Article
- Sexual Functioning and Depressive Symptoms in Women with Postpartum Thyroiditis.Diagnostics (Basel, Switzerland) · 2025Article
- The Role of Gut Microbiota Dysbiosis in Erectile Dysfunction: From Pathophysiology to Treatment Strategies.Microorganisms · 2025Review
- An L-shaped association between lymphocyte-to-monocyte ratio and erectile dysfunction in NHANES 2001-2004.Scientific reports · 2025Article
- Do inflammation and relational motivation coordinate having better sex? The interplay between C-reactive protein and relational approach motivation on sexual well-being.Brain, behavior, and immunity · 2025Article
- Dyadic and Sexual Functioning in Psoriasis: A Comparative Study in the Turkish Population.Sisli Etfal Hastanesi tip bulteni · 2025Article
- The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States.Scientific reports · 2024Article
- Causal relationship between immune cells, inflammatory cytokines, metabolites, and erectile dysfunction: a two-sample Mendelian randomization study.Translational andrology and urology · 2024Article
- Cardiometabolic Disorder and Erectile Dysfunction.Cell biochemistry and biophysics · 2024Review
- Combined influence of nutritional and inflammatory status and breast cancer: findings from the NHANES.BMC public health · 2024Article
- Causal associations of psoriasis with male sexual and reproductive health: a univariable and multivariable Mendelian randomization study.Archives of dermatological research · 2024Article
- Is erectile dysfunction associated with osteoarthritis and rheumatoid arthritis? Insights from a population-based study.Sexual medicine · 2024Article
- Piezo1 activation induces relaxation of the pudendal artery and corpus cavernosum.Frontiers in physiology · 2023Article
- Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionMale and female sexual dysfunction (SD) is considered a multifactorial condition. Numerous studies have shown the involvement of inflammatory processes in this pathological condition. Sexual intercourse requires healthy and functioning vessels to supply the pelvic region in both males and females, generating penile erection and clitoral and vaginal lubrication, respectively. Cardiovascular diseases and associated risk factors may contribute negatively to pelvic blood flow, possibly through immune system activation.
aimThe study aimed to address the correlation between vascular inflammation driven by immune system activation and SD in males and females.
methodsA literature review was performed to identify articles addressing male and female SD and vascular inflammation. Key words included "male and female sexual dysfunction," "vascular inflammation," "iliac and pudendal arteries dysfunction," "genitourinary tract," and "blood flow."
main outcome measuresManagement of systemic and local inflammation may be a useful alternative to improve SD and reduce the risk of cardiovascular diseases in the future.
resultsIncreased levels of cytokines and chemokines have been detected in humans and animals with hypertension, obesity, and diabetic conditions. Chronic activation of the innate immune system, especially by pathogen- or damage-associated molecular patterns, and metabolic-related disorders may act as triggers further contributing to an increased inflammatory condition. Due to the reduced size of vessels, SD and retinal vascular impairments have been shown to be predictive factors for cardiovascular diseases. Therefore, considering that blood flow to the genitalia is essential for sexual function, endothelial dysfunction and vascular remodeling, secondary to chronic immune system activation, may be implicated in male and female vasculogenic SD.
conclusionsSeveral conditions appear to play a role in SD. In the present review, we have identified a role for the immune system in generating vascular and tissue impairments contributing to erectile dysfunction and female SD. Calmasini FB, Klee N, Webb RC, et al. Impact of Immune System Activation and Vascular Impairment on Male and Female Sexual Dysfunction. Sex Med Rev 2019;7:604-613.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.