Evidence map›Paper›PMID 31326251›Full record

ArticleVaccine2019

Rabies vaccine and immunoglobulin supply and logistics: Challenges and opportunities for rabies elimination in Kenya.

Gati Wambura, Athman Mwatondo, Mathew Muturi, Carolyne Nasimiyu, Diorbhail Wentworth, Katie Hampson, Philet Bichanga, Collins Tabu, Samuel Juma, Isaac Ngere and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Vaccine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 33 citations in OpenAlex.

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  16. Global Landscape of Encephalitis: Key Priorities to Reduce Future Disease Burden.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Gati WamburaCenter for Global Health Research, Kenya Medical Institute of Research, Kisumu, Kenya.
Athman MwatondoZoonotic Disease Unit, Ministry of Health and Ministry of Agriculture, Livestock and Fisheries, Nairobi, Kenya.
Mathew MuturiZoonotic Disease Unit, Ministry of Health and Ministry of Agriculture, Livestock and Fisheries, Nairobi, Kenya.
Carolyne NasimiyuZoonotic Disease Unit, Ministry of Health and Ministry of Agriculture, Livestock and Fisheries, Nairobi, Kenya.
Diorbhail WentworthThe Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
Katie HampsonThe Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
Philet BichangaMinistry of Health, County Government of Makueni, Kenya.
Collins TabuNational Vaccines and Immunization Program, Ministry of Health, Nairobi, Kenya.
Samuel JumaNational Vaccines and Immunization Program, Ministry of Health, Nairobi, Kenya.
Isaac NgereWashington State University - Global Health Program, Nairobi, Kenya.
S M ThumbiCenter for Global Health Research, Kenya Medical Institute of Research, Kisumu, Kenya; Washington State University - Global Health Program, Nairobi, Kenya; Rabies Free Africa, Washington State University, Pullman, WA, USA; Paul G. Allen School for Global Animal Health, Washington State University, Pullman, USA. Electronic address: thumbi.mwangi@wsu.edu.
Ministry of Agriculture Livestock and Fisheries · KEMinistry of Health · KEUniversity of Glasgow · GBWashington State Department of Health · USKenya Medical Research Institute · KE

Funding

Wellcome Trust 110330Wellcome Trust 110330/Z/15/ZWellcome Trust 207569Wellcome Trust 207569/Z/17/ZWorld Health Organization 001
6 · The paper itself

Abstract

Prompt provision of post-exposure-prophylaxis (PEP) including vaccines and rabies immunoglobulin (RIG) to persons bitten by suspect rabid dogs is a key strategy to eliminating human deaths from dog-mediated rabies in Kenya by 2030. We assessed the availability, forecasting and supply chain logistics for rabies PEP in Kenya, compared with the system used for vaccines in the expanded program of immunization (routine vaccines). Semi-structured questionnaires capturing data on forecasting, procurement, distribution, cold chain and storage, monitoring and reporting for routine vaccines and rabies vaccines and RIG were administered to 35 key personnel at the national, county, sub-county and health facility levels in five counties. Results showed large variability in PEP availability (stockouts ranged from 3 to 36 weeks per year) with counties implementing rabies elimination activities having shorter stockouts. PEP is administered intramuscularly using the 5-dose Essen regimen (day 0, 3, 7, 14 and 28). PEP costs to bite patients were reported to range from 10 to 15 US dollars per dose; RIG was seldom available. A less robust supply and logistics infrastructure is used for rabies PEP compared to routine vaccines. Forecasting and monitoring mechanisms for rabies PEP was poor in the study counties. The supply of vaccines from the national to the sub-national level is mainly through two government agencies and a private agency. Since government decentralization, the National Vaccine and Immunization Program has remained as the main supplier of the routine vaccines, playing a lesser role in the supply of rabies biologicals. Adoption of the dose-saving intradermal route for PEP administration, reduction of PEP costs to patients, and placing rabies vaccines within the routine vaccines supply and logistics system would significantly improve PEP availability and accessibility to persons at risk of rabies; a critical step to achieving elimination of human deaths from rabies.

Indexed as

ImmunoglobulinsOrganization and AdministrationHealth Services AccessibilityHumansImmunologic FactorsKenyaPost-Exposure ProphylaxisRabiesRabies VaccinesSurveys and QuestionnairesImmunoglobulinsImmunologic FactorsRabies VaccinesImmunoglobulinsKenyaPEPRabiesVaccines

Identifiers

PMID31326251
PMCPMC7612384
OpenAlexW2959760634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.