Evidence map›Paper›PMID 31325968›Full record

ArticleJournal of neuroinflammation2019

The retinal environment induces microglia-like properties in recruited myeloid cells.

Scott W McPherson, Neal D Heuss, Ute Lehmann, Heidi Roehrich, Md Abedin, Dale S Gregerson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

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  12. Microglia and Microglia-Like Cells: Similar but Different.Frontiers in cellular neuroscience · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Scott W McPhersonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 6th Street SE, LRB Room 314, Minneapolis, MN, 55455, USA. mcphe003@umn.edu.ORCID http://orcid.org/0000-0003-4050-8805
Neal D HeussDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 6th Street SE, LRB Room 314, Minneapolis, MN, 55455, USA.
Ute LehmannDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 6th Street SE, LRB Room 314, Minneapolis, MN, 55455, USA.
Heidi RoehrichDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 6th Street SE, LRB Room 314, Minneapolis, MN, 55455, USA.
Md AbedinDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 6th Street SE, LRB Room 314, Minneapolis, MN, 55455, USA.
Dale S GregersonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 6th Street SE, LRB Room 314, Minneapolis, MN, 55455, USA.
University of Minnesota · US

Funding

Visual TestingP30EY011374 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI NEWMAN, ERIC A · 1996 to 2019
$8.8M
VISUAL NEUROSCIENCE TRAINING PROGRAMT32EY007133 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCLOON, STEVEN C · 1991 to 2010
$2.0M
Immune-mediated Neuroprotection of Retinal Ganglion CellsR01EY021003 · NEI · UNIVERSITY OF MINNESOTA · PI GREGERSON, DALE SANNES · 2010 to 2012
$1.3M
Retinal innate immunity: Functional analysis of resident and recruited cellsR01EY025209 · NEI · UNIVERSITY OF MINNESOTA · PI GREGERSON, DALE SANNES · 2016 to 2018
$1.1M
NEI NIH HHS P30 EY011374NEI NIH HHS P30-EY011374NEI NIH HHS R01 EY021003NEI NIH HHS R01-EY021003NEI NIH HHS R01 EY025209NEI NIH HHS R01-EY025209NEI NIH HHS T32 EY007133NEI NIH HHS T32-EY07133-17
6 · The paper itself

Abstract

backgroundMicroglia are essential to the development of the CNS and its homeostasis. Our prior findings suggested a niche model to describe the behaviors of retinal microglia. Here, we ask whether new myeloid cells recruited to the retina are constrained to resemble endogenous microglia morphologically and functionally.

methodsUse of CD11c

resultsWe found that the origin of new GFP

conclusionsThe results support the idea that GFP

Indexed as

AnimalsCell DifferentiationCellular MicroenvironmentMiceMice, TransgenicMicrogliaMyeloid CellsRetinaInjury responseMicrogliaMyeloid cellsOriginRetina

Identifiers

PMID31325968
PMCPMC6642741
OpenAlexW2962719641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.