Evidence map›Paper›PMID 31325802›Full record

Trial reportPsychoneuroendocrinology2019

Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.

Jennifer L Kruse, Joshua Hyong-Jin Cho, Richard Olmstead, Lin Hwang, Kym Faull, Naomi I Eisenberger, Michael R Irwin

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. BrainFrontiers in immunology · 2021
    Pooled it
  3. Pooled it
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  19. Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder.Advances in experimental medicine and biology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jennifer L KruseCousins Center for Psychoneuroimmunology, University of California Los Angeles, United States; Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, United States.
Joshua Hyong-Jin ChoCousins Center for Psychoneuroimmunology, University of California Los Angeles, United States; Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, United States. Electronic address: hjcho@mednet.ucla.edu.
Richard OlmsteadCousins Center for Psychoneuroimmunology, University of California Los Angeles, United States; Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, United States.
Lin HwangJane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, United States; Pasarow Mass Spectrometry Laboratory, University of California Los Angeles, United States.
Kym FaullJane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, United States; Pasarow Mass Spectrometry Laboratory, University of California Los Angeles, United States.
Naomi I EisenbergerCousins Center for Psychoneuroimmunology, University of California Los Angeles, United States; Department of Psychology, University of California Los Angeles, United States.
Michael R IrwinCousins Center for Psychoneuroimmunology, University of California Los Angeles, United States; Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, United States.
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Clinical and Translational Science InstituteKL2TR000122 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$4.5M
Inflammation-Induced Depressed Mood: The Role of Social Neurocognitive MechanismsR01MH091352 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EISENBERGER, NAOMI ILANA · 2010 to 2013
$1.7M
Sleep loss as a vulnerability factor for inflammation induced depressive symptoms in older womenK23AG049085 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHO, JOSHUA HYONG-JIN · 2015 to 2019
$950k
Depression Response to Fast-Acting Treatments: Inflammation and Reward MechanismsK23MH116127 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KRUSE, JENNIFER · 2018 to 2021
$790k
NCATS NIH HHS KL2 TR000122NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NIA NIH HHS K23 AG049085NIMH NIH HHS K23 MH116127NIMH NIH HHS R01 MH091352
6 · The paper itself

Abstract

Inflammation has an important physiological influence on mood and behavior. Kynurenine metabolism is hypothesized to be a pathway linking inflammation and depressed mood, in part through the impact of kynurenine metabolites on glutamate neurotransmission in the central nervous system. This study evaluated whether the circulating concentrations of kynurenine and related compounds change acutely in response to an inflammatory challenge (endotoxin administration) in a human model of inflammation-induced depressed mood, and whether such metabolite changes relate to mood change. Adults (n = 115) were randomized to receive endotoxin or placebo. Mood (Profile of Mood States), plasma cytokine (interleukin-6, tumor necrosis factor-α) and metabolite (kynurenine, tryptophan, kynurenic acid, quinolinic acid) concentrations were repeatedly measured before the intervention, and at 2 and 6 h post-intervention. Linear mixed models were used to evaluate relationships between mood, kynurenine and related compounds, and cytokines. Kynurenine, kynurenic acid, and tryptophan (but not quinolinic acid) concentrations changed acutely (p's all <0.001) in response to endotoxin as compared to placebo. Neither kynurenine, kynurenic acid nor tryptophan concentrations were correlated at baseline with cytokine concentrations, but all three were significantly correlated with cytokine concentrations over time in response to endotoxin. Quinolinic acid concentrations were not correlated with cytokine concentrations either before or following endotoxin treatment. In those who received endotoxin, kynurenine (p = 0.049) and quinolinic acid (p = 0.03) positively correlated with depressed mood, although these findings would not survive correction for multiple testing. Changes in tryptophan and kynurenine pathway metabolites did not mediate the relationship between cytokines and depressed mood. Further work is necessary to clarify the pathways leading from inflammation to depressed mood in humans.

Indexed as

AdultAffectCytokinesDepressionEndotoxinsFemaleHumansInflammationInterleukin-6Kynurenic AcidKynurenineMaleMiddle AgedQuinolinic AcidSex FactorsTryptophanCytokinesEndotoxinsInterleukin-6Kynurenic AcidKynurenineQuinolinic AcidTryptophanTumor Necrosis Factor-alphaDepressionExperimental designInflammationKynurenine metabolismSex differences

Identifiers

PMID31325802
PMCPMC6842695
OpenAlexW2954367215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.