ArticleRedox biology2019
A novel NOX2 inhibitor attenuates human neutrophil oxidative stress and ameliorates inflammatory arthritis in mice.
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Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Dysregulated immunometabolism in gut inflammation.Acta biochimica et biophysica Sinica · 2026Review
- NOX2 Contributes to High-Frequency Outer Hair Cell Vulnerability in the Cochlea.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- NADPH oxidases: redox regulation of cell homeostasis and disease.Physiological reviews · 2025Review
- Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis.Journal of advanced research · 2025Review
- Improved Synthesis of Effective 3-(Indolin-6-yl)-4-(International journal of molecular sciences · 2025Article
- Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome.Journal of advanced research · 2024Article
- Corilagin Inhibits Neutrophil Extracellular Trap Formation and Protects against Hydrochloric Acid/Lipopolysaccharide-Induced Acute Lung Injury in Mice by Suppressing the STAT3 and NOX2 Signaling Pathways.Antioxidants (Basel, Switzerland) · 2024Article
- Structure, Activation, and Regulation of NOX2: At the Crossroad between the Innate Immunity and Oxidative Stress-Mediated Pathologies.Antioxidants (Basel, Switzerland) · 2023Review
- Anti-Arthritic Effect of Edaravone Against Complete Freund Adjuvant Induced Arthritis via Osteoclast Differentiation and HIF-1α-VEGF-ANG-1 Axis.Drug design, development and therapy · 2023Article
- Neutrophil activation and NETosis are the predominant drivers of airway inflammation in an OVA/CFA/LPS induced murine model.Respiratory research · 2022Article
- NADPH Oxidases in Aortic Aneurysms.Antioxidants (Basel, Switzerland) · 2022Review
- Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- PFKL, a novel regulatory node for NOX2-dependent oxidative burst and NETosis.Journal of Zhejiang University. Science. B · 2022Article
- Article
- Antioxidant Analogue 6-Amino-2,4,5-Trimethylpyridin-3-ol Ameliorates Experimental Colitis in Mice.Digestive diseases and sciences · 2021Article
- Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs.Frontiers in pharmacology · 2021Article
- Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients.BioMed research international · 2021Article
- Galuminox: Preclinical validation of a novel PET tracer for non-invasive imaging of oxidative stress in vivo.Redox biology · 2020Article
- Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents.Marine drugs · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Fu-Chao LiuCollege of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan.
Huang-Ping YuCollege of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan.
Po-Jen ChenDepartment of Cosmetic Science, Providence University, Taichung, 433, Taiwan; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan.
Hsuan-Wu YangGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan.
Shih-Hsin ChangGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan.
Cherng-Chyi TzengDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Department of Medical Research, Kaohsiung Medical University-Hospital, Kaohsiung, 807, Taiwan.
Wei-Jen ChengGraduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Department of Traditional Chinese Medicine, Center of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan.
You-Ren ChenDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Department of Medical Research, Kaohsiung Medical University-Hospital, Kaohsiung, 807, Taiwan.
Yeh-Long ChenDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Department of Medical Research, Kaohsiung Medical University-Hospital, Kaohsiung, 807, Taiwan. Electronic address: yeloch@kmu.edu.tw.
Tsong-Long HwangDepartment of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan; Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan, 333, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, 243, Taiwan. Electronic address: htl@mail.cgu.edu.tw.
Chang Gung University · TWKaohsiung Medical University · TWChang Gung University of Science and Technology · TWMing Chi University of Technology · TW
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophil infiltration plays a significant pathological role in inflammatory diseases. NADPH oxidase type 2 (NOX2) is a respiratory burst oxidase that generates large amounts of superoxide anion (O
Indexed as
AnimalsArthritisBiomarkersCalciumEndothelial CellsEnzyme InhibitorsExtracellular SpaceFreund's AdjuvantHumansMaleMiceMitogen-Activated Protein KinasesNADPH Oxidase 2NeutrophilsOxidative StressProtein BindingBiomarkersCalciumCybb protein, mouseEnzyme InhibitorsFreund's AdjuvantMitogen-Activated Protein KinasesNADPH Oxidase 2Proto-Oncogene Proteins c-aktReactive Oxygen SpeciesCYR5099Inflammatory arthritisNADPH oxidase 2NeutrophilReactive oxygen species
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Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.