Evidence map›Paper›PMID 31325331›Full record

ArticleEuropean journal of haematology2019

Productivity losses in patients with newly diagnosed multiple myeloma following stem cell transplantation and the impact of maintenance therapy.

Graham Jackson, Jayne Galinsky, David E C Alderson, Vijay K D'Souza, Vanessa Buchanan, Sujith Dhanasiri, Simon Walker

Open access · bronzeAbstract read
In one paragraph

Article in European journal of haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  9. Review
  10. Cost-Effectiveness of Post-Autotransplant Lenalidomide in Persons with Multiple Myeloma.Mediterranean journal of hematology and infectious diseases · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Graham JacksonNewcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0003-0756-969X
Jayne GalinskyMyeloma UK, Edinburgh, UK.
David E C AldersonCogentia Healthcare Consulting, Cambridge, UK.
Vijay K D'SouzaCogentia Healthcare Consulting, Cambridge, UK.
Vanessa BuchananCogentia Healthcare Consulting, Cambridge, UK.
Sujith DhanasiriCelgene International, Boudry, Switzerland.
Simon WalkerCogentia Healthcare Consulting, Cambridge, UK.
Cogent (United Kingdom) · GBBristol-Myers Squibb (Switzerland) · CHMyeloma UK · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GB

Funding

Celgene Corporation
6 · The paper itself

Abstract

objectiveThis study examined productivity losses in European patients with newly diagnosed multiple myeloma (NDMM) undergoing autologous stem cell transplantation (ASCT), to better understand and model the impact of NDMM and lenalidomide maintenance therapy on productivity from a patient and societal perspective.

methodsA cross-sectional online patient survey was conducted across the UK, Germany, France, Spain and Italy. A partitioned survival model was used to estimate productivity loss and the impact of maintenance therapy, using human capital (HC) and friction cost approaches.

resultsOf the 115 eligible survey respondents, 76.5% were economically active at the time of diagnosis and highlighted return to work as an important factor affecting their quality of life; only 39.1% of respondents were economically active post-ASCT. HC analyses estimated average total productivity losses per ASCT patient at EUR 290,601 over a 20-year period. Modelling the impact of maintenance therapy alone for these patients reduced average productivity losses by just over 10%.

conclusionPatients with NDMM aspire to engage in productive lives post-ASCT, but most are unable to do so. Access to treatments extending remission and supporting engagement in a productive life can have a positive impact both for patients and wider society.

Indexed as

Efficiency, OrganizationalAdultAgedAged, 80 and overCross-Sectional StudiesEuropeFemaleHematopoietic Stem Cell TransplantationHumansMaintenance ChemotherapyMaleMiddle AgedModels, TheoreticalMultiple MyelomaPopulation SurveillanceSocioeconomic Factorsautologous transplantationhealth services accessibilitymultiple myelomareturn to worksurveys and questionnaires

Identifiers

PMID31325331
PMCPMC6899492
OpenAlexW2963665143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.