Evidence map›Paper›PMID 31325330›Full record

ArticleProteins2020

Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5.

Shira Warszawski, Elya Dekel, Ivan Campeotto, Jennifer M Marshall, Katherine E Wright, Oliver Lyth, Orli Knop, Neta Regev-Rudzki, Matthew K Higgins, Simon J Draper and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Erythroid glucose transport in health and disease.Pflugers Archiv : European journal of physiology · 2020
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Shira WarszawskiDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Elya DekelDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Ivan CampeottoDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID 0000-0002-0814-619X
Jennifer M MarshallJenner Institute, University of Oxford, Oxford, UK.
Katherine E WrightDepartment of Life Sciences, Imperial College London, Sir Alexander Fleming Building, London, UK.
Oliver LythDepartment of Life Sciences, Imperial College London, Sir Alexander Fleming Building, London, UK.
Orli KnopDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Neta Regev-RudzkiDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Matthew K HigginsDepartment of Biochemistry, University of Oxford, Oxford, UK.
Simon J DraperJenner Institute, University of Oxford, Oxford, UK.ORCID 0000-0002-9415-1357
Jake BaumDepartment of Life Sciences, Imperial College London, Sir Alexander Fleming Building, London, UK.ORCID 0000-0002-0275-352X
Sarel J FleishmanDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-3177-7560
Weizmann Institute of Science · ILUniversity of Oxford · GBImperial College London · GB

Funding

European Research Council 815379Medical Research Council MR/K501281/1Wellcome TrustWellcome Trust 100993/Z/13/ZWellcome Trust 106917/Z/15/ZWellcome Trust 107366/Z/15/Z
6 · The paper itself

Abstract

Many human pathogens use host cell-surface receptors to attach and invade cells. Often, the host-pathogen interaction affinity is low, presenting opportunities to block invasion using a soluble, high-affinity mimic of the host protein. The Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) provides an exciting candidate for mimicry: it is highly conserved and its moderate affinity binding to the human receptor basigin (K

Indexed as

BasiginCarrier ProteinsErythrocytesHumansMalaria, FalciparumModels, MolecularPlasmodium falciparumProtein BindingProtozoan ProteinsBasiginCarrier ProteinsProtozoan ProteinsRH5 protein, Plasmodium falciparumdeep sequencinghigh-affinity designhost-pathogen interactionsPlasmodium falciparumRosetta

Identifiers

PMID31325330
PMCPMC6904230
OpenAlexW2963515335

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.