Evidence map›Paper›PMID 31325218›Full record

ArticleEnvironmental microbiology2019

Oral delivery of pancreatitis-associated protein by Lactococcus lactis displays protective effects in dinitro-benzenesulfonic-acid-induced colitis model and is able to modulate the composition of the microbiota.

Natalia M Breyner, Priscilla Bagano Vilas Boas, Gabriel Fernandes, Rodrigo D de Carvalho, Tatiana Rochat, Marie-Laure Michel, Florian Chain, Harry Sokol, Marcela de Azevedo, Anderson Myioshi and 4 more

Open access · greenAbstract read
In one paragraph

Article in Environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Natalia M BreynerMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Priscilla Bagano Vilas BoasMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Gabriel FernandesFiocruz Minas, Belo Horizonte, MG, Brazil.
Rodrigo D de CarvalhoFederal University of Minas Gerais (UFMG-ICB), Belo Horizonte, MG, Brazil.
Tatiana RochatVIM, INRA, 78350, Jouy en Josas, France.
Marie-Laure MichelMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Florian ChainMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Harry SokolMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Marcela de AzevedoMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Anderson MyioshiFederal University of Minas Gerais (UFMG-ICB), Belo Horizonte, MG, Brazil.
Vasco A AzevedoFederal University of Minas Gerais (UFMG-ICB), Belo Horizonte, MG, Brazil.
Philippe LangellaMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Luis G Bermúdez-HumaránMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.
Jean-Marc ChatelMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.ORCID 0000-0003-4967-1414
AgroParisTech · FRUniversidade Federal de Minas Gerais · BRFundação Oswaldo Cruz · BRVirologie et Immunologie Moléculaires · FR

Funding

Association Instituts CarnotCAPES-Cofecub 720/11Carnot QualimentCNPqConselho Nacional de Desenvolvimento Científico e Tecnológico
6 · The paper itself

Abstract

Antimicrobial peptides secreted by intestinal immune and epithelial cells are important effectors of innate immunity. They play an essential role in the maintenance of intestinal homeostasis by limiting microbial epithelium interactions and preventing unnecessary microbe-driven inflammation. Pancreatitis-associated protein (PAP) belongs to Regenerating islet-derived III proteins family and is a C-type (Ca

Indexed as

AnimalsAntimicrobial Cationic PeptidesBenzenesulfonatesColitisColonDextran SulfateDisease Models, AnimalGastrointestinal MicrobiomeInflammationLactococcus lactisMiceMice, Inbred C57BLPancreatitis-Associated ProteinsPeptidesAntimicrobial Cationic PeptidesBenzenesulfonatesDextran Sulfatedinitrobenzenesulfonic acidPancreatitis-Associated ProteinsPeptidesproIslet peptide, human

Identifiers

PMID31325218
PMCPMC6899824
OpenAlexW2963001710

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.