Evidence map›Paper›PMID 31325084›Full record

ArticleEndocrine2019

Adrenalectomy impairs vasoactive intestinal peptide-induced changes in food intake and plasma parameters.

Marcela Cristina Garnica-Siqueira, Andressa Bussetti Martins, Larissa Rugila Dos Stopa, Camila Franciele de Souza, Dimas Augusto Morozin Zaia, Cristiane Mota Leite, Cássia Thaïs Bussamra Vieira Zaia, Ernane Torres Uchôa

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Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marcela Cristina Garnica-SiqueiraLaboratory of Neuroendocrine Physiology and Metabolism, Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil.
Andressa Bussetti MartinsLaboratory of Neuroendocrine Physiology and Metabolism, Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil.
Larissa Rugila Dos StopaLaboratory of Neuroendocrine Physiology and Metabolism, Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil.
Camila Franciele de SouzaLaboratory of Neuroendocrine Physiology and Metabolism, Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil.
Dimas Augusto Morozin ZaiaDepartment of Chemistry, Laboratory of Prebiotic Chemistry, State University of Londrina, Londrina, PR, Brazil.
Cristiane Mota LeiteUniversidade Norte do Paraná, Londrina, PR, Brazil.
Cássia Thaïs Bussamra Vieira ZaiaLaboratory of Neuroendocrine Physiology and Metabolism, Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil. ctbvzaia@uel.br.ORCID 0000-0002-3867-2158
Ernane Torres UchôaLaboratory of Neuroendocrine Physiology and Metabolism, Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil. ernane_uchoa@yahoo.com.br.
Universidade Estadual de Londrina · BRUniversidade Norte do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study is to evaluate the effects of adrenalectomy (ADX) and glucocorticoid in the changes induced by intracerebroventricular (ICV) administration of vasoactive intestinal peptide (VIP) on food intake and plasma parameters, as well as VIP receptor subtype 2 (VPAC2) mRNA expression in different hypothalamic nuclei of male rats.

methodsMale Wistar rats (260-280 g) were subjected to ADX or sham surgery, 7 days before the experiments. Half of ADX animals received corticosterone (ADX + CORT) in the drinking water. Animals with 16 h of fasting received ICV microinjection of VIP or saline (0.9% NaCl). After 15 min: (1) animals were fed, and the amount of food ingested was quantified for 120 min; or (2) animals were euthanized and blood was collected for biochemical measurements. Determination of VPAC2 mRNA levels in LHA, ARC, and PVN was performed from animals with microinjection of saline.

resultsVIP treatment promoted the anorexigenic effect, which was not observed in ADX animals. Microinjection of VIP also induced an increase in blood plasma glucose and corticosterone levels, and a reduction in free fatty acid plasma levels, but adrenalectomy abolished these effects. In addition, adrenalectomy reduced mRNA expression of VPAC2 in the lateral hypothalamic area and arcuate nucleus, but not in the paraventricular nucleus.

conclusionsThese results suggest that adrenal glands are required for VIP-induced changes in food intake and plasma parameters, and these responses are associated with reduction in the expression of VPAC2 in the hypothalamus after adrenalectomy.

Indexed as

AdrenalectomyAnimalsArcuate Nucleus of HypothalamusBlood GlucoseCorticosteroneEatingFatty Acids, NonesterifiedHypothalamic Area, LateralMaleMicroinjectionsParaventricular Hypothalamic NucleusRatsRats, WistarReceptors, Vasoactive Intestinal Peptide, Type IIVasoactive Intestinal PeptideBlood GlucoseCorticosteroneFatty Acids, NonesterifiedReceptors, Vasoactive Intestinal Peptide, Type IIVasoactive Intestinal PeptideArcuate nucleus of the hypothalamusCorticosteroneFree fatty acidsGlycemiaVIPVPAC2 receptor expression

Identifiers

PMID31325084
OpenAlexW2964102637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.