ReviewMolecular neurobiology2020
Deciphering the Role of WNT Signaling in Metabolic Syndrome-Linked Alzheimer's Disease.
Review in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism.Cell reports. Medicine · 2026Article
- Aerobic exercise and metformin attenuate the cognitive impairment in an experimental model of type 2 diabetes mellitus: focus on neuroinflammation and adult hippocampal neurogenesis.Metabolic brain disease · 2025Article
- Impact of Mast Cell Activation on Neurodegeneration: A Potential Role for Gut-Brain Axis andNeurology international · 2024Review
- Insulin resistance as the molecular link between diabetes and Alzheimer's disease.World journal of diabetes · 2024Review
- Serum amyloid beta 42 levels correlated with metabolic syndrome and its components.Frontiers in endocrinology · 2024Article
- Inhibition of CXXC5 function reverses obesity-related metabolic diseases.Clinical and translational medicine · 2022Article
- Molecular Insights to the Wnt Signaling During Alzheimer's Disorder: a Potential Target for Therapeutic Interventions.Journal of molecular neuroscience : MN · 2022Review
- Targeting hypercoagulation to alleviate Alzheimer's disease progression in metabolic syndrome.International journal of obesity (2005) · 2022Review
- Article
- A global analysis on the differential regulation of RNA binding proteins (RBPs) by TNF-α as potential modulators of metabolic syndromes.BBA advances · 2022Article
- Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome.Frontiers in cell and developmental biology · 2022Review
- Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis.Frontiers in physiology · 2022Review
- Relationship Between Metabolic Syndrome and Bone Health - An Evaluation of Epidemiological Studies and Mechanisms Involved.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been well established in recent research that there is a strong correlation between metabolic syndrome (MetS) and Alzheimer's disease (AD). However, the knowledge of exact mechanistic behind this association remains elusive. It has been reported in recent studies that inflammation and hypercoagulation are pivotal to the pathophysiology of MetS-induced AD. It is rather captivating that aberrant Wnt signaling pathway has been found to be implicated in each of the four conditions, i.e., inflammation, hypercoagulation, MetS, and AD. Deregulation of Wnt signaling has been affiliated with numerous brain pathologies, including Alzheimer's disease and insulin resistance. In recent past, it has been proposed that the Wnt pathway can act as a central integrator of metabolic signals from peripheral organs to the brain, which would constitute a unique character for Wnt signaling in glucose metabolism. The review educates in what way distinct components of Wnt signaling impact effector mediators of inflammation, hypercoagulation, which in turn decelerate the progression of AD in MetS. Furthermore, components of Wnt signaling, namely, Wnt3a and GSK-3β, interlink MetS and AD. The review opines a contemporary hypothesis that Wnt signaling is implicated in the pathogenesis of MetS-induced AD via impacting inflammation and coagulation. Hence, targeting Wnt signaling could be a novel approach to halt the progression of MetS-linked AD.
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Registered trials
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