Observational studyJournal of neurology2019
The long-term prognosis of patients with delirium in the acute phase of stroke: PRospective Observational POLIsh Study (PROPOLIS).
Observational study in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The associations of post-stroke delirium with outcomes: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Impact of delirium on acute stroke outcomes: A systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Associations Between Stroke Localization and Delirium: A Systematic Review and Meta-Analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Pooled it
- Association between post-intravenous thrombolysis delirium and 90-day functional outcomes in patients with acute ischemic stroke.Frontiers in psychiatry · 2026Article
- Caregivers' Knowledge, Attitudes, and Practices Regarding Risk Factors and Management of Post-Stroke Delirium Among Stroke Patients: A Cross-Sectional Study.International journal of general medicine · 2026Article
- Association between stress hyperglycemia ratio and post-stroke delirium in critically ill patients with ischemic stroke: an MIMIC-IV database analysis.European journal of medical research · 2025Article
- Delirium is a Potential Predictor of Unfavorable Long-term Functional Outcomes in Patients with Acute Ischemic Stroke: A Prospective Observational Study.Journal of inflammation research · 2025Article
- Delirium following mechanical thrombectomy for ischemic stroke - individuals at risk, imaging biomarkers and prognosis.Frontiers in aging neuroscience · 2025Article
- Post-stroke delirium is a predictor of prolonged hospital stay and poor functional outcome at 3 months.Frontiers in stroke · 2025Article
- Is delirium after stroke associated with dysregulation of hypothalamic pituitary axis?Frontiers in stroke · 2025Article
- Network analysis of neuropsychiatric, cognitive, and functional complications of stroke: implications for novel treatment targets.Psychiatry and clinical neurosciences · 2024Article
- Five-year stroke prognosis. Influence of post-stroke delirium and post-stroke dementia on mortality and disability (Research Study - Part of the PROPOLIS Study).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Article
- Impact of delirium on the outcome of stroke: a prospective, observational, cohort study.Journal of neurology · 2022Observational
- The Role of Vascular Risk Factors in Post-Stroke Delirium: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Heart rate variability and delirium in acute non-cardioembolic stroke: a prospective, cross-sectional, cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Effect of Programmed Comprehensive Nursing for Postoperative Delirium in Intensive Care Unit Patients.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Clinical utility of brain computed tomography in prediction of post-stroke delirium.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Delirium Post-Stroke: Short- and Long-Term Effect on Depression, Anxiety, Apathy and Aggression (Research Study-Part of PROPOLIS Study).Journal of clinical medicine · 2020Article
- Delirium Post-Stroke-Influence on Post-Stroke Dementia (Research Study-Part of the PROPOLIS Study).Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeDelirium is a very common neurobehavioral complication after stroke, but its influence on long-term outcome is not well characterized. The objective of the study was to determine the prognostic significance of delirium for functional status, nursing home admission, and mortality in a large cohort of patients with delirium in the acute phase of stroke assessed 3 and 12 months after stroke.
methodsAll stroke survivors included in PROPOLIS were followed up (n = 682). Outcome data included: discharge destination, recurrence of stroke, cardiovascular complications, functional activity and mobility, nursing home admission, and mortality.
resultsPatients with delirium were discharged to another hospital or nursing home significantly more often than those presenting without delirium. The 3- and 12-month post-stroke mortality rates were higher in delirious patients (OR 6.41 CI 3.76-10.92; p < 0.001 and OR 5.17 CI 3.36-7.96; p < 0.001). When considering 3-month mortality, higher age, modified Rankin Scale prior to admission and temperature between 1 and 3 days after admission, as well delirium, pneumonia and more severe neurological deficits on admission were independent risk factors. For 12-month mortality, the independent risk factors were higher age and modified Rankin Scale post-stroke, delirium, and history of respiratory diseases prior to stroke. Patients with delirium were more likely to live in nursing homes 3 and 12 months after stroke and were more disabled than patients without delirium.
conclusionsDelirium in acute phase of stroke negatively influences the long-term prognosis. A study addressing the effect of early recognition and treatment of identified modifiable risk factors for adverse long-term outcomes is urgently needed to decrease bad prognosis within this population.
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