Evidence map›Paper›PMID 31324962›Full record

SynthesisSocial psychiatry and psychiatric epidemiology2019

Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis.

Nicla Manzari, Karen Matvienko-Sikar, Franco Baldoni, Gerard W O'Keeffe, Ali S Khashan

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Social psychiatry and psychiatric epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 6 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 6 syntheses or guidelines pooled it, 163 citations in OpenAlex.

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  18. Prenatal Exposure to Wildfire and Autism in Children.Environmental science & technology · 2026
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nicla ManzariDepartment of Psychology, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0001-8687-2683
Karen Matvienko-SikarSchool of Public Health, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0003-2777-6581
Franco BaldoniDepartment of Psychology, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-4547-749X
Gerard W O'KeeffeDepartment of Anatomy and Neuroscience and Cork Neuroscience Centre, University College Cork, Cork, Ireland. g.okeeffe@ucc.ie.ORCID http://orcid.org/0000-0001-5149-0933
Ali S KhashanThe Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland. a.khashan@ucc.ie.ORCID http://orcid.org/0000-0002-7499-9406
University College Cork · IEUniversity of Bologna · IT

Funding

Science Foundation Ireland INFANT-12/RC/2272
6 · The paper itself

Abstract

purposeExposure to prenatal stress has been reported to affect the risk of adverse neurodevelopmental outcomes in the offspring; however, there is currently no clear consensus. The aim of this systematic review and meta-analysis was to examine the existing literature on the association between prenatal stress and autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) in the offspring.

methodsBased on a registered protocol, we searched several electronic databases for articles in accordance with a detailed search strategy. We performed this study following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA).

resultsPrenatal stress was significantly associated with an increased risk of both ASD (pooled OR 1.64 [95% CI 1.15-2.34]; I

conclusionsThis study suggests that prenatal stress may be associated with ASD and ADHD; however, several limitations in the reviewed literature should be noted including significant heterogeneity and there is a need for carefully controlled future studies in this area.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMaternal ExposureNeurodevelopmental DisordersPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsStress, PsychologicalAttention-deficit/hyperactivity disorderAutism spectrum disorderMental healthPregnancyPrenatal maternal stress

Identifiers

PMID31324962
OpenAlexW2996035231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.