SynthesisInternational journal of colorectal disease2019
Quality of life in patients treated for anal carcinoma-a systematic literature review.
Synthesis in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Improving our understanding of the quality of life of patients with metastatic or recurrent/persistent anal cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Impact of surgical approach and anastomosis distance on low anterior resection syndrome.BMC surgery · 2026Article
- Quality of Life and Healthcare Experiences of Patients with Anal Cancer: A Mixed-Methods Study.Current oncology (Toronto, Ont.) · 2026Article
- Histological assessment of radiotherapy-induced injury in the anal canal: an exploratory study.International journal of colorectal disease · 2025Article
- Perception of cure and quality of life in anal cancer survivors.Acta oncologica (Stockholm, Sweden) · 2025Article
- Predictors of acute and late diarrhea in the treatment of anal cancer with concurrent chemoradiotherapy.Acta oncologica (Stockholm, Sweden) · 2025Observational
- Interstitial HDR brachytherapy for anal cancer-results and quality of life.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- Impact of the risk-adapted Nordic anal cancer group consensus guidelines on the contouring of the elective clinical target volume in anal cancer.Acta oncologica (Stockholm, Sweden) · 2025Article
- Anal cancer impact among people with HIV infection - a matched cohort study.Ecancermedicalscience · 2025Article
- ROAR-A: re-optimization based Online Adaptive Radiotherapy of anal cancer, a prospective phase II trial protocol.BMC cancer · 2024Article
- Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment.Cancers · 2023Review
- Article
- Influence of radiation treatment technique (IMRT vs. 3D-RT) on acute toxicity and prognostic factors for survival for anal cancer.Scientific reports · 2022Article
- Challenges and controversies patients and (health care) professionals experience in managing vaginal, vulvar, penile or anal cancer: The SILENCE study.European journal of cancer care · 2022Article
- Patient-Reported Bowel and Urinary Function in Long-Term Survivors of Squamous Cell Carcinoma of the Anus Treated With Definitive Intensity Modulated Radiation Therapy And Concurrent Chemotherapy.International journal of radiation oncology, biology, physics · 2022Article
- Leukocyte subtyping predicts for treatment failure and poor survival in anal squamous cell carcinoma.BMC cancer · 2022Article
- Quality of life in patients treated with radiochemotherapy for primary diagnosis of anal cancer.Scientific reports · 2022Article
- Local excision and chemoradiation for clinical node-negative anal adenocarcinoma.Surgical oncology · 2021Article
- Article
- A Novel Remote Follow-Up Tool Based on an Instant Messaging/Social Media App for the Management of Patients With Low Anterior Resection Syndrome: Pilot Prospective Self-Control Study.JMIR mHealth and uHealth · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeAnal cancer is a mainly treated with chemoradiotherapy. A small number of patients undergo salvage surgery. There are few published studies investigating quality of life and functional outcome after treatment for anal cancer. The aim of this review was to explore the literature and identify areas for further research.
methodsA search was conducted in Medline using MESH terms related to anal cancer and quality of life. Two investigators selected and reviewed articles based on titles and abstracts. Three investigators read and reviewed the included articles and collected relevant data. The included articles were evaluated using the minimum standard checklist, and key findings were summarised in a chart.
resultsSome 15 articles, and a total of 802 patients, were deemed eligible. The results differed slightly among the studies. The incidence of symptoms such as fatigue, nausea, insomnia and appetite loss was higher than among healthy volunteers. Bowel function, urinary function and sexual function were negatively affected. Some studies found that, compared with the normal population, anal cancer survivors scored clinically significant worse in the functional scales in QLQ-C30.
conclusionIn conclusion, it is apparent that several functional problems affect the quality of life of patients with anal cancer. There are few studies which have investigated quality of life after treatment for anal cancer. Interventions to address issues related to anal cancer treatment may improve long-term quality of life in this patient group.
trial registrationCRD42017059787.
Indexed as
Identifiers
31324957What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.