ArticleScientific reports2019
Contrasting Roles of Cannabidiol as an Insecticide and Rescuing Agent for Ethanol-induced Death in the Tobacco Hornworm Manduca sexta.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The Use ofCannabis and cannabinoid research · 2022Pooled it
- Biopesticidal Potential of theInternational journal of molecular sciences · 2026Article
- Hermaphroditism inPlants (Basel, Switzerland) · 2026Review
- Hemp (International journal of molecular sciences · 2026Review
- Repellent, Lethal Activity, and Synergism ofPlants (Basel, Switzerland) · 2025Article
- Assessing the adaptive role of cannabidivarinic acid (CBDVA) in aphid defense in Cannabis sativa.Journal of cannabis research · 2025Article
- The behavioral, physiological, and biochemical responses of Lumbriculus variegatus exposed to cannabidiol and its metabolites.Environmental toxicology and chemistry · 2025Article
- Solid-state fermentation of hemp waste: enhancing the performance ofFrontiers in bioengineering and biotechnology · 2025Article
- Article
- Mathematical modeling predicts that endemics by generalist insects are eradicated if nearly all plants produce constitutive defense.Scientific reports · 2024Article
- Larvicidal Activity of Hemp Extracts and Cannabidiol against the Yellow Fever MosquitoInsects · 2024Article
- An enteric ultrastructural surface atlas of the model insectiScience · 2024Article
- Evaluating the impact of light quality on plant-herbivore interactions using hemp as the model system.Environmental entomology · 2024Article
- Building a community-driven bioinformatics platform to facilitateGigaByte (Hong Kong, China) · 2024Article
- Cannabinoids function in defense against chewing herbivores inHorticulture research · 2023Article
- Article
- Correlations among morphological and biochemical traits in high-cannabidiol hemp (Plant direct · 2023Article
- The conserved endocannabinoid anandamide modulates olfactory sensitivity to induce hedonic feeding in C. elegans.Current biology : CB · 2023Article
- Hemp Waste as a Substrate forInsects · 2023Article
- Assessing the adaptive role of cannabidiol (CBD) inFrontiers in plant science · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cannabis sativa, also known as marijuana or hemp, produces a non-psychoactive compound cannabidiol (CBD). To investigate the defensive role of CBD, a feeding preference assay was performed with tobacco hornworm Manduca sexta. The larvae clearly show feeding preference towards the Cannabis tissue containing low CBD over high CBD. While the larva avoided the high CBD diet, we investigated detrimental effects of CBD in the insects' diet. Contrasted to the performance on low CBD-infused artificial diet (AD), larvae reared on the high CBD diet suffer significantly reduced growth and increased mortality. Through testing different carriers, we found that the increase of EtOH in the diet is negatively correlated with insect development and behaviors. Notably, CBD treatment significantly improved ethanol-intoxicated larval survival rate by 40% and also improved diet searching activity, resulting in increased diet consumption. Electrophysiology results revealed that the CBD-treated ganglia had delayed but much larger response with electric stimuli in comparison to the larvae reared on AD only and EtOH-added diet. Our results show CBDs' defensive role against pest insects, which suggests its possible use as an insecticide. We also provide evidence that CBD alleviates alcohol-induced stress; consequently, improving the performance and viability of M. sexta larvae.
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