Evidence map›Paper›PMID 31324855›Full record

ArticleScientific reports2019

PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival.

Georgios Batsios, Pavithra Viswanath, Elavarasan Subramani, Chloe Najac, Anne Marie Gillespie, Romelyn Delos Santos, Abigail R Molloy, Russell O Pieper, Sabrina M Ronen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
  2. Article
  3. International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Multi-task Learning for Gaussian Graphical Regressions with High Dimensional Covariates.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2024
    Article
  7. Article
  8. Article
  9. Cancers · 2023
    Review
  10. Review
  11. Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  12. Review
  13. Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Biomedicines · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Georgios BatsiosDepartment of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Pavithra ViswanathDepartment of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Elavarasan SubramaniDepartment of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Chloe NajacDepartment of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Anne Marie GillespieDepartment of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Romelyn Delos SantosDepartment of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Abigail R MolloyDepartment of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States.
Russell O PieperDepartment of Neurological Surgery, Helen Diller Research Center, 1450 3rd Street, University of California, 94143, San Francisco, CA, United States.
Sabrina M RonenDepartment of Radiology and Biomedical Imaging, Mission Bay Campus, 1700 4th Street, Byers Hall, University of California, 94158, San Francisco, CA, United States. sabrina.ronen@ucsf.edu.
Neurological Surgery · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Metabolic Reprogramming in Brain TumorsR01CA172845 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RONEN, SABRINA MIRIAM · 2013 to 2022
$6.3M
Metabolic Imaging of Brain Tumor Response to TherapyR01CA197254 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RONEN, SABRINA MIRIAM · 2016 to 2020
$3.2M
NCI NIH HHS R01 CA172845NCI NIH HHS R01 CA197254
6 · The paper itself

Abstract

70-90% of low-grade gliomas and secondary glioblastomas are characterized by mutations in isocitrate dehydrogenase 1 (IDHmut). IDHmut produces the oncometabolite 2-hydroxyglutarate (2HG), which drives tumorigenesis in these tumors. The phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway represents an attractive therapeutic target for IDHmut gliomas, but noninvasive indicators of drug target modulation are lacking. The goal of this study was therefore to identify magnetic resonance spectroscopy (MRS)-detectable metabolic biomarkers associated with IDHmut glioma response to the dual PI3K/(mTOR) inhibitor XL765.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAstrocytesBrain NeoplasmsCell Cycle ProteinsCell Line, TransformedGliomaGlucoseGlutamineGlutaratesHumansIsocitrate DehydrogenaseKaplan-Meier EstimateMiceNeoplasm ProteinsNuclear Magnetic Resonance, BiomolecularAdaptor Proteins, Signal Transducingalpha-hydroxyglutarateCell Cycle ProteinsEIF4EBP1 protein, humanGlucoseGlutamineGlutaratesIsocitrate DehydrogenaseMTOR protein, humanNeoplasm ProteinsPhosphatidylinositol 3-KinasesQuinoxalinesRibosomal Protein S6 KinasesSulfonamidesTOR Serine-Threonine KinasesXL765

Identifiers

PMID31324855
PMCPMC6642106
OpenAlexW2963110900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.