Trial reportScientific reports2019
Accurate Detection of Dobutamine-induced Haemodynamic Changes by Kino-Cardiography: A Randomised Double-Blind Placebo-Controlled Validation Study.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04772807 (Validation of Kinocardiography, a New Technology Measuring Cardiac Mechanical Activity Via Accelerometers and Gyroscopes), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validation of Kinocardiography, a New Technology Measuring Cardiac Mechanical Activity Via Accelerometers and Gyroscopes
Who cites it
22 citing papers in PubMed.
- Effects of acquisition device, sampling rate, and record length on kinocardiography during position-induced haemodynamic changes.Biomedical engineering online · 2021Trial
- Clinical Readiness of Hemodynamic Estimation from Cardiac Vibration Signals: An Endpoint-Specific Critical Review.Annals of biomedical engineering · 2026Review
- Heart rate variability during wakefulness reflects sleep apnea indicators but remains context-dependent.Frontiers in physiology · 2026Article
- Evidence of effective cardiovascular countermeasures during spaceflights: insights from wearable monitoring.NPJ microgravity · 2025Article
- Fully automated template matching method for ECG-free heartbeat detection in cardiomechanical signals of healthy and pathological subjects.Physical and engineering sciences in medicine · 2025Article
- Estimating V̇OFrontiers in sports and active living · 2025Article
- Smartphone-Derived Seismocardiography: Robust Approach for Accurate Cardiac Energy Assessment in Patients with Various Cardiovascular Conditions.Sensors (Basel, Switzerland) · 2024Article
- Cardiac output estimation using ballistocardiography: a feasibility study in healthy subjects.Scientific reports · 2024Article
- The kinocardiograph for assessment of fluid status in patients with acute decompensated heart failure.ESC heart failure · 2023Article
- ECG-Free Heartbeat Detection in Seismocardiography and Gyrocardiography Signals Provides Acceptable Heart Rate Variability Indices in Healthy and Pathological Subjects.Sensors (Basel, Switzerland) · 2023Article
- Heartbeat Detection in Gyrocardiography Signals without Concurrent ECG Tracings.Sensors (Basel, Switzerland) · 2023Article
- ECG-Free Heartbeat Detection in Seismocardiography Signals via Template Matching.Sensors (Basel, Switzerland) · 2023Article
- Non-invasive cardiac kinetic energy distribution: a new marker of heart failure with impaired ejection fraction (KINO-HF).Frontiers in cardiovascular medicine · 2023Article
- Mechanocardiography-Based Measurement System Indicating Changes in Heart Failure Patients during Hospital Admission and Discharge.Sensors (Basel, Switzerland) · 2022Article
- Investigating Cardiorespiratory Interaction Using Ballistocardiography and Seismocardiography-A Narrative Review.Sensors (Basel, Switzerland) · 2022Review
- Detection of Aortic Valve Opening and Estimation of Pre-Ejection Period in Forcecardiography Recordings.Bioengineering (Basel, Switzerland) · 2022Article
- The kinocardiograph for assessment of changes in haemodynamic load in patients with chronic heart failure with reduced ejection fraction.ESC heart failure · 2021Article
- Kinocardiography Derived from Ballistocardiography and Seismocardiography Shows High Repeatability in Healthy Subjects.Sensors (Basel, Switzerland) · 2021Article
- Closed-Loop Multiscale Computational Model of Human Blood Circulation. Applications to Ballistocardiography.Frontiers in physiology · 2021Article
- Wearable Sensors Incorporating Compensatory Reserve Measurement for Advancing Physiological Monitoring in Critically Injured Trauma Patients.Sensors (Basel, Switzerland) · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasive remote detection of cardiac and blood displacements is an important topic in cardiac telemedicine. Here we propose kino-cardiography (KCG), a non-invasive technique based on measurement of body vibrations produced by myocardial contraction and blood flow through the cardiac chambers and major vessels. KCG is based on ballistocardiography and measures 12 degrees-of-freedom (DOF) of body motion. We tested the hypothesis that KCG reliably assesses dobutamine-induced haemodynamic changes in healthy subjects. Using a randomized double-blinded placebo-controlled crossover study design, dobutamine and placebo were infused to 34 volunteers (25 ± 2 years, BMI 22 ± 2 kg/m², 18 females). Baseline recordings were followed by 3 sessions of increasing doses of dobutamine (5, 10, 20 μg/kg.min) or saline solution. During each session, stroke volume (SV) and cardiac output (CO) were determined by echocardiography and followed by a 90 s KCG recording. Measured linear accelerations and angular velocities were used to compute total Kinetic energy (iK) and power (Pmax). KCG sorted dobutamine infusion vs. placebo with 96.9% accuracy. Increases in SV and CO were correlated to iK (r = +0.71 and r = +0.8, respectively, p < 0.0001). Kino-cardiography, with 12-DOF, allows detecting dobutamine-induced haemodynamic changes with a high accuracy and present a major improvement over single axis ballistocardiography or seismocardiography.
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