ArticleScientific reports2019
Distinct epigenetic profiles in children with perinatally-acquired HIV on antiretroviral therapy.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts.PLoS pathogens · 2024Pooled it
- DNA methylation signatures of inflammation in youth living with perinatally-acquired HIV.Clinical epigenetics · 2026Article
- Is the molecular microenvironment of the latent HIV reservoir predictable using deep learning approaches?Journal of virology · 2026Review
- HIV associated epigenetic trends and chronic diseases: insights into the hidden burden of chronic infection.Clinical epigenetics · 2026Review
- Epigenetic modifications and immune responses in HIV-infected infants: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape.Frontiers in immunology · 2025Article
- A multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV.Clinical epigenetics · 2024Article
- Prenatal exposure to common infections and newborn DNA methylation: A prospective, population-based study.Brain, behavior, and immunity · 2024Article
- Epigenetic Aging and Musculoskeletal Outcomes in a Cohort of Women Living With HIV.The Journal of infectious diseases · 2024Article
- A multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among people with HIV.Research square · 2024Article
- Persistent accelerated epigenetic ageing in a longitudinal cohort of vertically infected HIV-positive adolescents.Journal of neurovirology · 2023Article
- Epigenetic signature of exposure to maternalEpigenomics · 2022Article
- Epigenetic regulation of pediatric and neonatal immune responses.Pediatric research · 2022Review
- Article
- Deciphering DNA Methylation in HIV Infection.Frontiers in immunology · 2021Review
- DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections.Clinical epigenetics · 2020Article
- Behavioral Functioning and Quality of Life in South African Children Living with HIV on Antiretroviral Therapy.The Journal of pediatrics · 2020Article
- Epigenome-wide association scan identifies methylation sites associated with HIV infection.Epigenomics · 2020Article
- Differences in inducibility of the latent HIV reservoir in perinatal and adult infection.JCI insight · 2020Article
- High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells.Journal of pharmacological and toxicological methodsArticle
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Perinatally-acquired HIV has persistent effects on long-term health outcomes, even after early treatment. We hypothesize that epigenetic indicators, such as DNA methylation, may elucidate cellular processes that explain these effects. Here, we compared DNA methylation profiles in whole blood from 120 HIV-infected children on antiretroviral therapy (ART) and 60 frequency age-matched HIV-uninfected children aged 4-9 years in Johannesburg, South Africa. Using an individual CpG site approach, we found 1,309 differentially-methylated (DM) CpG sites between groups, including 1,271 CpG sites that were hyper-methylated in the HIV-infected group and 38 CpG sites that were hypo-methylated in the HIV-infected group. Six hyper-methylated CpG sites were in EBF4, which codes for a transcription factor involved in B-cell maturation. The top hypomethylated site was in the promoter region of NLRC5, encoding a transcription factor that regulates major histocompatibility complex (MHC) class I molecule expression. Using a differentially-methylated region (DMR) approach, we found 315 DMRs between groups, including 28 regions encompassing 686 CpG sites on chromosome 6. A large number of the genes identified in both the CpG site and DMR approaches were located in the MHC region on chromosome 6, which plays an important role in the adaptive immune system. This study provides the first evidence that changes in the epigenome are detectable in children with perinatally-acquired HIV infection on suppressive ART started at an early age.
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