ArticleNature communications2019
Evidence against tetrapod-wide digit identities and for a limited frame shift in bird wings.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Evolution of limb and digit identity genes since the tetrapod ancestor.Nature communications · 2026Article
- Degeneration and adaptive evolution of digits in ratite birds.Molecular biology and evolution · 2026Article
- Proximal phalanges of digit 1 have different identities in the forelimbs and hindlimbs of the mouse.Scientific reports · 2025Article
- Article
- Insights into digit evolution from a fate map study of the forearm using Chameleon, a new transgenic chicken line.Development (Cambridge, England) · 2024Article
- The dinosaurian femoral head experienced a morphogenetic shift from torsion to growth along the avian stem.Proceedings. Biological sciences · 2022Article
- Theories, laws, and models in evo-devo.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Review
- Selection on Phalanx Development in the Evolution of the Bird Wing.Molecular biology and evolution · 2021Article
- The cichlid oral and pharyngeal jaws are evolutionarily and genetically coupled.Nature communications · 2021Article
- Evidence of five digits in embryonic horses and developmental stabilization of tetrapod digit number.Proceedings. Biological sciences · 2020Article
- A single-cell transcriptomic atlas of the developing chicken limb.BMC genomics · 2019Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
In crown group tetrapods, individual digits are homologized in relation to a pentadactyl ground plan. However, testing hypotheses of digit homology is challenging because it is unclear whether digits represent distinct and conserved gene regulatory states. Here we show dramatic evolutionary dynamism in the gene expression profiles of digits, challenging the notion that five digits have conserved developmental identities across amniotes. Transcriptomics shows diversity in the patterns of gene expression differentiation of digits, although the anterior-most digit of the pentadactyl limb has a unique, conserved expression profile. Further, we identify a core set of transcription factors that are differentially expressed among the digits of amniote limbs; their spatial expression domains, however, vary between species. In light of these results, we reevaluate the frame shift hypothesis of avian wing evolution and conclude only the identity of the anterior-most digit has shifted position, suggesting a 1,3,4 digit identity in the bird wing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.