ArticleNature communications2019
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 222 papers.
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222citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
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222 citing papers in PubMed, 369 citations in OpenAlex.
- Single-cell transcriptomics and machine-learning reveal M1 macrophage-driven progression from minimal change disease to focal segmental glomerulosclerosis.Renal failure · 2026Article
- Glial cells in neuropathic pain.Physiological reviews · 2026Review
- Signal-integrated control of immune and reparative programs establishes blood-derived fibrocytes reprogrammable toward induced pluripotency.Biology open · 2026Article
- Reduced colony-stimulating factor 1 receptor expression in myeloid cells has limited impact on chronic lymphocytic leukaemia progression.British journal of haematology · 2026Article
- CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis.Development (Cambridge, England) · 2026Article
- Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pathogenic myeloid phenotypes drive disease pathology in a novel human neurohistiocytosis model.Blood · 2026Article
- Article
- CSF1R regulates monocyte subset differentiation and intracellular metabolism.Nature communications · 2026Article
- Targeting Post-Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual-Action Approach for Antioxidant and Immune Modulation.Advanced healthcare materials · 2026Article
- Macrophages in embryonic development.Nature reviews. Immunology · 2026Review
- Depletion and replacement of tissue-resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus.Development (Cambridge, England) · 2026Article
- CSF1R-related leukoencephalopathy: experimental models and potential for treatment.Disease models & mechanisms · 2026Review
- Human IL-34 Deficiency Primes Microglia Toward Alzheimer's Disease-Associated States.medRxiv : the preprint server for health sciences · 2026Article
- CSF1R and macrophage infiltration: Integrated magnetic resonance imaging radiomics and deep learning-driven models for the preoperative assessment of glioma.Chinese medical journal · 2026Article
- Review
- Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties.Neuron · 2026Article
- Computational discovery of novel colony-stimulating factor-1 receptor as a potential therapeutic biomarker in osteosarcoma and a novel inhibitor from herbal sources.Oncology letters · 2026Article
- Genetic-Environmental Programming of Microglial Identity: Shaping Spatiotemporal Dynamics in Neurodevelopment and Neurodevelopmental Diseases.Cellular and molecular neurobiology · 2026Review
- Blood vessel-resident macrophages safeguard blood and vessel integrity in zebrafish.Nature immunology · 2026Article
162 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors at 8 institutions in 7 countries.
Rocío RojoThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0001-9686-3377
Anna RaperThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0003-0949-9963
Derya D OzdemirThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Lucas LefevreThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0003-0925-7411
Kathleen GrabertThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0002-5628-9400
Evi Wollscheid-LengelingThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Barry BradfordThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0002-4007-1685
Melanie CarusoThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0001-9159-5422
Iveta GazovaThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0002-0787-9463
Alejandra SánchezThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Zofia M LisowskiThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0002-1323-9593
Joana AlvesThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0003-3131-9834
Irene Molina-GonzalezThe MRC University of Edinburgh Centre for Reproductive Health, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.ORCID http://orcid.org/0000-0001-5966-0351
Hayk DavtyanDepartment of Neurobiology and Behavior, University of California Irvine, 3014 Gross Hall 845 Health Sciences Rd, Irvine, CA, 92697-1705, USA.ORCID http://orcid.org/0000-0001-8554-6456
Rebecca J LodgeUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
James D GloverThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Robert WallaceThe Department of Orthopedic Surgery, University of Edinburgh, Chancellor's Building, Edinburgh BioQuarter, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
David A D MunroUK Dementia Research Institute, The University of Edinburgh, Chancellor's Building, Edinburgh BioQuarter, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
Eyal DavidDepartment of Immunology, Weizmann Institute of Science, 234 Herzl St., Rehovot, 7610001, Israel.
Ido AmitDepartment of Immunology, Weizmann Institute of Science, 234 Herzl St., Rehovot, 7610001, Israel.ORCID http://orcid.org/0000-0003-2968-877X
Véronique E MironThe MRC University of Edinburgh Centre for Reproductive Health, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Josef PrillerUK Dementia Research Institute, The University of Edinburgh, Chancellor's Building, Edinburgh BioQuarter, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
Stephen J JenkinsUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.ORCID http://orcid.org/0000-0002-0233-5424
Giles E HardinghamUK Dementia Research Institute, The University of Edinburgh, Chancellor's Building, Edinburgh BioQuarter, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
Mathew Blurton-JonesDepartment of Neurobiology and Behavior, University of California Irvine, 3014 Gross Hall 845 Health Sciences Rd, Irvine, CA, 92697-1705, USA.ORCID http://orcid.org/0000-0002-7770-7157
Neil A MabbottThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.ORCID http://orcid.org/0000-0001-7395-1796
Kim M SummersMater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD, 4102, Australia.ORCID http://orcid.org/0000-0002-7084-4386
Peter HohensteinThe Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
David A HumeMater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD, 4102, Australia. David.Hume@uq.edu.au.
Clare PridansUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. clare.pridans@ed.ac.uk.ORCID http://orcid.org/0000-0001-9423-557X
Roslin Institute · GBCentre for Inflammation Research · GBUK Dementia Research Institute · GBMRC Centre for Reproductive Health · GBTranslational Research Institute · AUUniversity of California, Irvine · USWeizmann Institute of Science · ILUniversity of Edinburgh · GB
Funding
Medical Research Council MC_PC_16031Medical Research Council MR/M010341/1Medical Research Council MR/M019969/1Medical Research Council MR/M020827/1Medical Research Council MR/S000763/1Wellcome Trust
Abstract
The proliferation, differentiation and survival of mononuclear phagocytes depend on signals from the receptor for macrophage colony-stimulating factor, CSF1R. The mammalian Csf1r locus contains a highly conserved super-enhancer, the fms-intronic regulatory element (FIRE). Here we show that genomic deletion of FIRE in mice selectively impacts CSF1R expression and tissue macrophage development in specific tissues. Deletion of FIRE ablates macrophage development from murine embryonic stem cells. Csf1r
Indexed as
Sequence DeletionAnimalsBase SequenceCell DifferentiationCell ProliferationDisease Models, AnimalEmbryonic Stem CellsEpidermal Growth FactorFemaleGene Expression RegulationGenes, fmsMacrophage Colony-Stimulating FactorMacrophagesMaleMiceMice, Inbred C57BLCsf1r protein, mouseEmr4 protein, mouseEpidermal Growth FactorMacrophage Colony-Stimulating FactorReceptors, Granulocyte-Macrophage Colony-Stimulating Factor
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