SynthesisNature communications2019
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.
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In one paragraph
Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.
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74citing papers in PubMed, 3 pooled it
13.4field-weighted citation impact, top 1% of its field
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Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- A meta-analysis and polygenic score study identifies novel genetic markers for waist-hip ratio in African populations.Obesity (Silver Spring, Md.) · 2024Pooled it
- Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.Genome medicine · 2024Pooled it
- Heritability and Genetics of Type 2 Diabetes Mellitus in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.Journal of diabetes research · 2020Pooled it
- Harnessing data science to control non-communicable diseases in Africa: a systematic review and gap analysis.Communications medicine · 2026Article
- Causal relationship between epigenetic markers and type 2 diabetes in West African populations: a Mendelian randomisation analysis.Diabetologia · 2026Article
- Insights into the genetic aetiology of diabetes in Africa.EBioMedicine · 2026Review
- Rare genetic diseases associated with G-quadruplex-induced replication stress.Communications biology · 2026Review
- African immigrants with type 2 diabetes present with three physiologic subtypes: implications for screening, diagnosis and treatment.BMJ open diabetes research & care · 2026Article
- The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective.International journal of molecular sciences · 2026Review
- Insights into human history and complex traits from the genomes of African populations.Molecular biology and evolution · 2026Review
- Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.Blood advances · 2025Article
- Article
- Multi-cohort genome-wide association analyses reveal loci underlying circulating liver enzyme levels in African-ancestry populations.Research square · 2025Article
- Phenotypic and Genetic Diversity in Diabetes Across Populations.The Journal of clinical endocrinology and metabolism · 2025Review
- Three Loci Affecting Variance of Body Mass Index in African Americans and Sub-Saharan Africans.Genetic epidemiology · 2025Article
- Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.Diabetologia · 2025Article
- Optimized methods for scRNA-seq and snRNA-seq of skeletal muscle stored in nucleic acid stabilizing preservative.Communications biology · 2025Article
- Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations.Diabetologia · 2024Article
- Novel KCNQ2 missense variant expands the genotype spectrum of DEE7.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Lipidomics profiling and circulating triglyceride concentrations in sub-Saharan African individuals.Scientific reports · 2024Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 11 institutions in 5 countries.
Adebowale A AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.ORCID http://orcid.org/0000-0002-3105-3231
Norann A ZaghloulDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201, MD, USA.
Guanjie ChenCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.ORCID http://orcid.org/0000-0002-5745-5618
Ayo P DoumateyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
Carmen C LeitchDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201, MD, USA.
Timothy L HostelleyDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201, MD, USA.
Jessica E NesmithDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201, MD, USA.
Jie ZhouCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.ORCID http://orcid.org/0000-0002-0827-9101
Daniel ShrinerCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
Olufemi FasanmadeUniversity of Lagos, Lagos, Nigeria.
Godfrey OkaforUniversity of Nigeria Teaching Hospital, Enugu, Nigeria.
Benjamin EghanUniversity of Science and Technology, Kumasi, Ghana.
Kofi Agyenim-BoatengUniversity of Science and Technology, Kumasi, Ghana.
Settara ChandrasekharappaNational Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA.
Jokotade AdeleyeCollege of Medicine, University of Ibadan, Ibadan, Nigeria.
William BalogunCollege of Medicine, University of Ibadan, Ibadan, Nigeria.
Samuel OwusuUniversity of Ghana Medical School, Accra, Ghana.
Albert AmoahUniversity of Ghana Medical School, Accra, Ghana.
Joseph AcheampongUniversity of Science and Technology, Kumasi, Ghana.
Thomas JohnsonUniversity of Lagos, Lagos, Nigeria.
Johnnie OliUniversity of Nigeria Teaching Hospital, Enugu, Nigeria.
Clement AdebamowoDepartment of Epidemiology and Public Health; Institute of Human Virology; Greenebaum Comprehensive Cancer Center, School of Medicine, University of Maryland, Baltimore, 21201, MD, USA.
South Africa Zulu Type 2 Diabetes Case-Control Study
Francis CollinsNational Institutes of Health, Bethesda, 20892, MD, USA.
Georgia DunstonNational Human Genome Center at Howard University, Washington, 20059, DC, USA.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, MD, USA. rotimic@mail.nih.gov.ORCID http://orcid.org/0000-0001-5759-053X
National Institutes of Health · USCentre for Human Genetics · GBUniversity of Cambridge · GBUniversity of Maryland, Baltimore · USKwame Nkrumah University of Science and Technology · GHUniversity of Ghana · GHUniversity of Ibadan · NGUniversity of Lagos · NGUniversity of Nigeria Teaching Hospital · NGNational Human Genome Research Institute · USWellcome Sanger Institute · GB
Funding
Genetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7MGenetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RYAN, ALICE S. · 2005 to 2019
$17.3MEXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9MNHGRI/DIR Genomics CoreZICHG200346 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI CHANDRASEKHARAPPA, SETTARA · 2010 to 2025
$14.5MDiabetes, Obesity, and Metabolic ComplicationsT32DK098107 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI TAYLOR, SIMEON I. · 2015 to 2025
$2.4MBasal body regulation of glucose homeostasisR01DK102001 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2014 to 2018
$1.7MInteraction of exocrine and endocrine pancreas in obesity ciliopathiesF31DK115179 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI HOSTELLEY, TIMOTHY LAIN · 2018 to 2019
$66kMINORITY INTERNATIONAL RESEARCH TRAINING GRANTT37TW000041 · FIC · HOWARD UNIVERSITY · PI ADAMS-CAMPBELL, LUCILE L · 1993 to 1998
–FIC NIH HHS T37 TW000041Intramural NIH HHS ZIA HG200362NHGRI NIH HHS ZIA HG200362NIDDK NIH HHS F31 DK115179NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK102001NIDDK NIH HHS T32 DK098107NIGMS NIH HHS R25 GM055036
Abstract
Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group. We analyze ~18 million autosomal SNPs in 5,231 individuals from Nigeria, Ghana and Kenya. We identify a previously-unreported genome-wide significant locus: ZRANB3 (Zinc Finger RANBP2-Type Containing 3, lead SNP p = 2.831 × 10
Indexed as
Genetic Association StudiesAfrica, NorthernAnimalsApoptosisBase SequenceBlood GlucoseCRISPR-Cas SystemsDiabetes Mellitus, Type 2Disease Models, AnimalDNA HelicasesFemaleGene EditingGene Knockout TechniquesGenetic Predisposition to DiseaseGenotypeGhanaBlood GlucoseDNA HelicasesGlucoseInsulinRNA, Small InterferingTCF7L2 protein, humanTranscription Factor 7-Like 2 ProteinZRANB3 protein, human
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