ArticleThe Journal of experimental medicine2019
RRAS2 shapes the TCR repertoire by setting the threshold for negative selection.
Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- ETS1 Promotes Aerobic Glycolysis and Growth in Head and Neck Squamous Cell Carcinoma by Targeting RRAS2.Biochemical genetics · 2025Article
- Ras-related protein 2 limits vascular smooth muscle cell phenotypic switching and abdominal aortic aneurysm development.Nature communications · 2025Article
- Article
- Role of cross-reactivity in cellular immune targeting of influenza A M1Frontiers in immunology · 2022Article
- Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua.eLife · 2021Article
- ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.Cell reports · 2021Article
- Identification of mFrontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signal strength controls the outcome of αβ T cell selection in the thymus, resulting in death if the affinity of the rearranged TCR is below the threshold for positive selection, or if the affinity of the TCR is above the threshold for negative selection. Here we show that deletion of the GTPase RRAS2 results in exacerbated negative selection and above-normal expression of positive selection markers. Furthermore,
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Registered trials
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