Evidence map›Paper›PMID 31324654›Full record

ArticleHospital pediatrics2019

The ACT NOW Clinical Practice Survey: Gaps in the Care of Infants With Neonatal Opioid Withdrawal Syndrome.

Jessica N Snowden, A Akshatha, Robert D Annett, Margaret M Crawford, Abhik Das, Lori A Devlin, Rosemary D Higgins, Zhuopei Hu, Elizabeth Lindsay, Stephanie Merhar and 9 more

Abstract readMulticenter Study
In one paragraph

Article in Hospital pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Non-pharmacological care for opioid withdrawal in newborns.The Cochrane database of systematic reviews · 2020
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Neonatal opioid withdrawal syndrome: a review of the science and a look toward the use of buprenorphine for affected infants.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Review
  6. Variations and similarities in neonatal abstinence syndrome care and management across tertiary care hospitals in West Virginia.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Article
  7. Comparison of Two Morphine Dosing Strategies in the Management of Neonatal Abstinence Syndrome.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022
    Article
  8. Article
  9. Observational
  10. Article
  11. Hawai'i IDeA Center for Pediatric and Adolescent Clinical Trials.Hawai'i journal of health & social welfare · 2020
    Article
  12. Hawai'i Journal Watch.Hawai'i journal of health & social welfare · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jessica N SnowdenDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas; jsnowden@uams.edu.
A AkshathaKapiolani Women and Children's Hospital, Honolulu, Hawaii.
Robert D AnnettUniversity of Mississippi Medical Center, Jackson, Mississippi.
Margaret M CrawfordRTI International, Research Triangle Park, North Carolina.
Abhik DasRTI International, Research Triangle Park, North Carolina.
Lori A DevlinDepartment of Pediatrics, University of Louisville, Louisville, Kentucky.
Rosemary D HigginsCollege of Health and Human Services, George Mason University, Fairfax, Virginia.
Zhuopei HuDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Elizabeth LindsayDepartment of Pediatrics, Section of Neonatology, Tulane University, New Orleans, Louisiana.
Stephanie MerharCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Clare Campbell NesmithDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Heather Pratt-ChavezHealth Sciences Center, University of New Mexico, Albuquerque, New Mexico.
Judith RossNemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware.
Alan E SimonEnvironmental Influences on Child Health Outcomes Program, National Institutes of Health, Bethesda, Maryland.
M Cody SmithWest Virginia University Medical Center, Morgantown, West Virginia.
Christine B TurleyDepartment of Pediatrics, College of Medicine, University of South Carolina, Columbia, South Carolina.
Anita WaldenDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Leslie YoungUniversity of Vermont Medical Center, Burlington, Vermont; and.
Bonny WhalenChildren's Hospital at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Funding

Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials NetworkU24OD024957 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI COURTNEY, SHERRY, OUNPRASEUTH, SONGTHIP T. · 2016 to 2024
$80.8M
Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027880 · NICHD · STANFORD UNIVERSITY · PI VAN MEURS, KRISA PAGE · 1991 to 2015
$6.1M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027851 · NICHD · EMORY UNIVERSITY · PI CARLTON, DAVID · 1991 to 2015
$5.0M
IMproving Pediatric Access to Clinical Trials in Vermont (IMPACT VT)UG1OD024955 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kelly Jean Cowan, Leslie W Young · 2016 to 2026
$4.8M
MS-ISPCTN (Cycle 3)UG1OD024942 · OD · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joseph Marc Majure · 2016 to 2026
$4.7M
Sunflower Pediatric Clinical Trials (SPeCTr 3.0)UG1OD024943 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Ann M Davis, BRIDGETTE L. JONES · 2016 to 2026
$4.7M
Rhode Island Child Clinical Trials CollaborativeUG1OD024951 · OD · RHODE ISLAND HOSPITAL · PI THOMAS H CHUN, PHYLLIS A. DENNERY · 2016 to 2026
$4.7M
UNM Pediatric Clinical Trial Sites in IDeA State Pediatric Clinical Trial NetworkUG1OD024947 · OD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Jessie R. Maxwell, Hengameh H Raissy · 2016 to 2026
$4.6M
ISPCTN Pediatric Clinical Trials UnitUG1OD024946 · OD · DARTMOUTH-HITCHCOCK CLINIC · PI Tyler Hartman, Paul E. Palumbo · 2016 to 2026
$4.6M
The DE Nemours/duPont Hospital for Children IDeA States Pediatric Clinical Trials Network SiteUG1OD024958 · OD · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI Robert E Akins, Thao-Ly Tam Phan-Vo · 2016 to 2026
$4.5M
Montana Pediatric Clinical Trials SiteUG1OD024952 · OD · UNIVERSITY OF MONTANA · PI Emily Hall, Erin O'Brien Semmens · 2016 to 2026
$4.4M
NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD053089NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD021364NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068244NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD087226NICHD NIH HHS UG1 HD087229NICHD NIH HHS UG1 HD090904NIH HHS U24 OD024957NIH HHS UG1 OD024942NIH HHS UG1 OD024943NIH HHS UG1 OD024944NIH HHS UG1 OD024945NIH HHS UG1 OD024946NIH HHS UG1 OD024947NIH HHS UG1 OD024948NIH HHS UG1 OD024949NIH HHS UG1 OD024950NIH HHS UG1 OD024951NIH HHS UG1 OD024952NIH HHS UG1 OD024953NIH HHS UG1 OD024954NIH HHS UG1 OD024955NIH HHS UG1 OD024956NIH HHS UG1 OD024958NIH HHS UG1 OD024959
6 · The paper itself

Abstract

objectivesThe incidence of neonatal opioid withdrawal syndrome (NOWS) has increased fivefold over the last 10 years. Standardized NOWS care protocols have revealed many improved patient outcomes. Our objective for this study is to describe results of a clinical practice survey of NOWS management practices designed to inform future clinical studies in the diagnosis and management of NOWS.

methodsA cross-sectional survey was administered to medical unit directors at 32 Institutional Development Award States Pediatric Clinical Trial Network and 22 Neonatal Research Network sites in the fall of 2017. Results are presented as both the number and percentage of positive responses. Ninety-five percent Wilson confidence intervals (CIs) were generated around estimates, and χ

resultsSixty-two responses representing 54 medical centers were received. Most participating NICU and non-ICU sites reported protocols for NOWS management, including NOWS scoring (98% NICU; 86% non-ICU), pharmacologic treatment (92% NICU; 64% non-ICU), and nonpharmacologic care (79% NICU; 79% non-ICU). Standardized protocols for pharmacologic care and weaning were reported more frequently in the NICU (92% [95% CI: 80%-97%] and 94% [95% CI: 83%-98%], respectively) compared with non-ICU settings (64% [95% CI: 39%-84%] for both) (

conclusionsObserved variations in care between NICUs and non-ICUs revealed opportunities for targeted interventions in training and standardized care plans in non-ICU sites.

Indexed as

Clinical ProtocolsAnalgesics, OpioidCross-Sectional StudiesHealth Care SurveysHumansInfant, NewbornNeonatal Abstinence SyndromeAnalgesics, Opioid

Identifiers

PMID31324654
PMCPMC6663517

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.