ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Bidirectional Associations Between Stress and Reward Processing in Children and Adolescents: A Longitudinal Neuroimaging Study.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- Prefrontal cortex development and its implications in mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Monoamine Loss and Functional Connectivity Alterations in Patients With Parkinson's Disease and Depression.CNS neuroscience & therapeutics · 2025Article
- Subcortical functional connectivity alterations in first-episode medication-naïve adolescents with major depressive disorder.European child & adolescent psychiatry · 2025Article
- Investigating Neural Reward Sensitivity in the School Grade Incentive Delay Task and Its Relation to Academic Buoyancy.Behavioral sciences (Basel, Switzerland) · 2025Article
- Testing a Reward-Processing Model of Negative Urgency in Women With and Without Binge Eating.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Neural mechanisms of reward processing in preadolescent irritability: Insights from the ABCD study.Journal of affective disorders · 2025Article
- Neural Reactivity to Social Reward Moderates the Association Between Social Media Use and Momentary Positive Affect in Adolescents.Affective science · 2024Article
- Ventral striatal-cingulate resting-state functional connectivity in healthy adolescents relates to later depression symptoms in adulthood.Journal of affective disorders · 2024Article
- Threat- and reward-related brain circuitry, perceived stress, and anxiety in adolescents during the COVID-19 pandemic: a longitudinal investigation.Social cognitive and affective neuroscience · 2024Article
- Neural sensitivity following stress predicts anhedonia symptoms: a 2-year multi-wave, longitudinal study.Translational psychiatry · 2024Article
- Effect of Tai Chi on Young Adults with Subthreshold Depression via a Stress-Reward Complex: A Randomized Controlled Trial.Sports medicine - open · 2023Article
- Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models.Neuroscience and biobehavioral reviews · 2023Review
- Pathways to Psychopathology Among Autistic Adults.Current psychiatry reports · 2023Review
- Neural Sensitivity following Stress Predicts Anhedonia Symptoms: A 2-Year Multi-wave, Longitudinal Study.Research square · 2023Article
- Amygdala and nucleus accumbens activation during reward anticipation moderates the association between life stressor frequency and depressive symptoms.Journal of affective disorders · 2023Article
- The interplay of childhood maltreatment and maternal depression in relation to the reward positivity in youth.Development and psychopathology · 2023Article
- Altered Reward Circuit Function Moderates the Relationship between Childhood Maltreatment and Depression Severity in Adolescents.Depression and anxiety · 2023Article
- Family income buffers the relationship between childhood adverse experiences and putamen volume.Developmental neurobiology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundAberrations in both neural reward processing and stress reactivity are associated with increased risk for mental illness; yet, how these two factors relate to each other remains unclear. Several studies suggest that stress exposure impacts reward function, thus increasing risk for psychopathology. However, the alternative hypothesis, in which reward dysfunction impacts stress reactivity, has been rarely examined. The current study aimed to test both hypotheses using a longitudinal design.
methodsParticipants were 38 children (23 girls; 61%) from a prospective cohort study. A standard stress-exposure measure was collected at 7 years of age. Children performed a well-validated imaging reward paradigm at age 10, and a standardized acute psychological stress laboratory protocol was administered both at age 10 and at age 13. Structural equation modeling was used to examine bidirectional associations between stress and neural response to reward anticipation.
resultsHigher exposure to stressful life events at age 7 predicted lower neural response to reward anticipation in regions of the basal ganglia at age 10, which included ventral caudate, nucleus accumbens, putamen, and globus pallidus. Lower response to reward anticipation in medial prefrontal and anterior cingulate cortex predicted higher stress reactivity at age 13.
conclusionsOur findings provide support for bidirectional associations between stress and reward processing, in that stress may impact reward anticipation, but also in that reduced reward anticipation may increase susceptibility to stress.
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