Trial reportEnvironment international2019
Effect of a 24-week randomized trial of an organic produce intervention on pyrethroid and organophosphate pesticide exposure among pregnant women.
Trial report in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Impact of organic foods on chronic diseases and health perception: a systematic review of the evidence.European journal of clinical nutrition · 2025Pooled it
- Pooled it
- Pesticide exposure and child growth in low- and middle-income countries: A systematic review.Environmental research · 2022Pooled it
- Urinary Glyphosate Concentrations among Pregnant Participants in a Randomized, Crossover Trial of Organic and Conventional Diets.Environmental health perspectives · 2023Trial
- Pesticide Residues, Gut Microbiota, and Gastrointestinal Outcomes: A Scoping Review of Human Evidence.Comprehensive reviews in food science and food safety · 2026Article
- Dietary guidelines adherence and pregnancy exposure to 10 classes of priority chemicals: an observational study in the Environmental influences on Child Health Outcomes Cohort.The American journal of clinical nutrition · 2026Observational
- First trimester urine glyphosate concentrations and gestational diabetes in nulliparas: a nested case-control study.Environmental health : a global access science source · 2025Article
- A study protocol for a randomized clinical trial on exposure and effects of pesticides consumption - the PEST-EXPO Brazil study.MethodsX · 2024Article
- Organic Food in Athletes Diet-Narrative Review of Alternative Products in Sports Nutrition.Nutrients · 2024Review
- A Comprehensive Analysis of Organic Food: Evaluating Nutritional Value and Impact on Human Health.Foods (Basel, Switzerland) · 2024Review
- Endocrine-disrupting chemicals and male reproductive health.Fertility and sterility · 2023Review
- Article
- Perceptions and experiences of environmental health and risks among Latina mothers in urban Los Angeles, California, USA.Environmental health : a global access science source · 2023Article
- Organic food consumption and fecundability in a preconception cohort study of Danish couples trying to conceive.Paediatric and perinatal epidemiology · 2023Article
- Perspective: Organic food consumption during pregnancy and the potential effects on maternal and offspring health.Advances in nutrition (Bethesda, Md.) · 2023Review
- Effects of the low-carb organic Mediterranean diet on testosterone levels and sperm DNA fragmentation.Current research in food science · 2023Article
- Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi-structured review from FIGO.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Review
- Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins.Environmental health : a global access science source · 2022Article
- Detection of Pyrethroids in Food by Immunofluorescence Enhanced Method Based on Three-Layer Core-Shell Structure Upconversion Materials.Foods (Basel, Switzerland) · 2022Article
- How much pesticide residue is in your diet? It depends on what you eat-and how it's grown.The American journal of clinical nutrition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundIntroduction of an organic diet can significantly reduce exposure to some classes of pesticides in children and adults, but no long-term trials have been conducted.
objectivesTo assess the effect of a long-term (24-week) organic produce intervention on pesticide exposure among pregnant women.
methodsWe recruited 20 women from the Idaho Women, Infants, and Children (WIC) program during their first trimester of pregnancy. Eligible women were nonsmokers aged 18-35 years who reported eating exclusively conventionally grown food. We randomly assigned participants to receive weekly deliveries of either organic or conventional fruits and vegetables throughout their second or third trimesters and collected weekly spot urine samples. Urine samples, which were pooled to represent monthly exposures, were analyzed for biomarkers of organophosphate (OP) and pyrethroid insecticides.
resultsFood diary data demonstrated that 66% of all servings of fruits and vegetables consumed by participants in the "organic produce" group were organic, compared to <3% in the "conventional produce" group. We collected an average of 23 spot samples per participant (461 samples total), which were combined to yield 116 monthly composites. 3-Phenoxybenzoic acid (3-PBA, a non-specific biomarker of several pyrethroids) was detected in 75% of the composite samples, and 3-PBA concentrations were significantly higher in samples collected from women in the conventional produce group compared to the organic produce group (0.95 vs 0.27 μg/L, p = 0.03). Another pyrethroid biomarker, trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, was detected more frequently in women in the conventional compared to the organic produce groups (16% vs 4%, p = 0.05). In contrast, we observed no statistically significant differences in detection frequency or concentrations for any of the four biomarkers of OP exposure quantified in this trial. DISCUSSION: To our knowledge, this is the first long-term organic diet intervention study, and the first to include pregnant women. These results suggest that addition of organic produce to an individual's diet, as compared to conventional produce, significantly reduces exposure to pyrethroid insecticides.
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