Evidence map›Paper›PMID 31324279›Full record

ReviewJournal of food and drug analysis2019

Revisit gut microbiota and its impact on human health and disease.

Rui-Xue Ding, Wei-Rui Goh, Ri-Na Wu, Xi-Qing Yue, Xue Luo, Wei Wei Thwe Khine, Jun-Rui Wu, Yuan-Kun Lee

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of food and drug analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05603403 (Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Placebo-Controlled Clinical Trial To Evaluate The Efficacy And Safety Of Probiatop In The Treatment Of Digestive Symptoms), which is not on this map. Cited by 109 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05603403 phase4completednot on this mapstarted 2022, after this paper: background citation

Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Placebo-Controlled Clinical Trial To Evaluate The Efficacy And Safety Of Probiatop In The Treatment Of Digestive Symptoms

TypeinterventionalSponsorAzidus BrasilRan2022 to 2023Enrolled150ConditionsSigns and Symptoms, DigestiveArmsProbiatop, Placebo
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Meta-Analysis: Randomized Trials ofFrontiers in immunology · 2021
    Pooled it
  4. Pooled it
  5. Significant changes in the fecal bacteriobiota richness and diversity in patients with relapsing-remitting multiple sclerosis compared to healthy individuals.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
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  10. Article
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  15. Nutrients · 2025
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rui-Xue DingCollege of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China.
Wei-Rui GohDepartment of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore.
Ri-Na WuCollege of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China.
Xi-Qing YueCollege of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China.
Xue LuoCollege of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China.
Wei Wei Thwe KhineDepartment of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore.
Jun-Rui WuCollege of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China.
Yuan-Kun LeeDepartment of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trillions of microbes have evolved with and continue to live on human beings. With the rapid advances in tools and technology in recent years, new knowledge and insight in cross-talk between the microbes and their hosts have gained. It is the aim of this work to critically review and summarize recent literature reports on the role of microbiota and mechanisms involved in the progress and development of major human diseases, which include obesity, hypertension, cardiovascular disease, diabetes, cancer, Inflammatory Bowel Disease (IBD), gout, depression and arthritis, as well as infant health and longevity.

Indexed as

Gastrointestinal MicrobiomeInfant HealthArthritisCardiovascular DiseasesDepressionDiabetes MellitusGoutHumansHypertensionInflammatory Bowel DiseasesNeoplasmsObesityDiseaseGut microbiotaHuman health

Identifiers

PMID31324279
PMCPMC9307029

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.