Evidence map›Paper›PMID 31324175›Full record

ArticleBMC public health2019

Home-based intervention to test and start (HITS) protocol: a cluster-randomized controlled trial to reduce HIV-related mortality in men and HIV incidence in women through increased coverage of HIV treatment.

T Mathenjwa, H-Y Kim, T Zuma, M Shahmanesh, J Seeley, P Matthews, S Wyke, N McGrath, B Sartorius, H M Yapa and 5 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 5 countries.

T MathenjwaAfrica Health Research Institute, Durban, South Africa. tmathenjwa@ahri.org.ORCID http://orcid.org/0000-0003-2436-9972
H-Y KimAfrica Health Research Institute, Durban, South Africa.
T ZumaAfrica Health Research Institute, Durban, South Africa.
M ShahmaneshAfrica Health Research Institute, Durban, South Africa.
J SeeleyAfrica Health Research Institute, Durban, South Africa.
P MatthewsAfrica Health Research Institute, Durban, South Africa.
S WykeUniversity of Glasgow, Glasgow, United Kingdom.
N McGrathAfrica Health Research Institute, Durban, South Africa.
B SartoriusFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
H M YapaAfrica Health Research Institute, Durban, South Africa.
O AdeagboAfrica Health Research Institute, Durban, South Africa.
A BlandfordUCL Interaction Centre, University College London, London, United Kingdom.
A DobraUniversity of Washington, Washington, USA.
T BäernighausenUniversity of Heidelberg, Heidelberg, Germany.
F TanserAfrica Health Research Institute, Durban, South Africa.
Africa Health Research Institute · ZALondon School of Hygiene & Tropical Medicine · GBCentre for the AIDS Programme of Research in South Africa · ZAHeidelberg University · DELondon Centre for Nanotechnology · GBUniversity of Glasgow · GBUniversity of Johannesburg · ZAUniversity of Washington · USUNSW Sydney · AU

Funding

Can HIV Hot-Spots be eradicated? An intervention to decrease HIV transmission to young women in rural KwaZulu-Natal South AfricaR01AI124389 · NIAID · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2016 to 2020
$2.1M
Department of Health RP-2017-08-ST2-008NIAID NIH HHS R01 AI124389NIH HHS R01- AI124389
6 · The paper itself

Abstract

backgroundTo realize the full benefits of treatment as prevention in many hyperendemic African contexts, there is an urgent need to increase uptake of HIV testing and HIV treatment among men to reduce the rate of HIV transmission to (particularly young) women. This trial aims to evaluate the effect of two interventions - micro-incentives and a tablet-based male-targeted HIV decision support application - on increasing home-based HIV testing and linkage to HIV care among men with the ultimate aim of reducing HIV-related mortality in men and HIV incidence in young women. METHODS/

designThis is a cluster randomized trial of 45 communities (clusters) in a rural area in the uMkhanyakude district of KwaZulu Natal, South Africa (2018-2021). The study is built upon the Africa Health Research Institute (AHRI)'s HIV testing platform, which offers annual home-based rapid HIV testing to individuals aged 15 years and above. In a 2 × 2 factorial design, individuals aged ≥15 years living in the 45 clusters are randomly assigned to one of four arms: i) a financial micro-incentive (food voucher) (n = 8); ii) male-targeted HIV specific decision support (EPIC-HIV) (n = 8); iii) both the micro incentives and male-targeted decision support (n = 8); and iv) standard of care (n = 21). The EPIC-HIV application is developed and delivered via a tablet to encourage HIV testing and linkage to care among men. A mixed method approach is adopted to supplement the randomized control trial and meet the study aims. DISCUSSION: The findings of this trial will provide evidence on the feasibility and causal impact of two interventions - micro-incentives and a male-targeted HIV specific decision support - on uptake of home-based HIV testing, linkage to care, as well as population health outcomes including population viral load, HIV related mortality in men, and HIV incidence in young women (15-30 years of age).

trial registrationThis trial was registered on 28 November 2018 on, identifier https://clinicaltrials.gov/ .

Indexed as

Decision Support TechniquesHome Care ServicesMotivationAdolescentAdultCluster AnalysisComputers, HandheldFactor Analysis, StatisticalFemaleHIVHIV InfectionsHumansIncidenceMaleMass ScreeningMiddle AgedCounsellingFinancial incentivesHIVHome-based HIV testingLinkage to care

Identifiers

PMID31324175
PMCPMC6642506
OpenAlexW2963247413

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.