ArticleViruses2019
Ubiquitous Carbohydrate Binding Modules Decorate 936 Lactococcal Siphophage Virions.
Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Phage host range: determinants, dynamics and applications.Nature reviews. Microbiology · 2026Review
- Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail.Science advances · 2025Article
- Lactococcal phage-host profiling through binding studies between cell wall polysaccharide types andMicrobial genomics · 2025Article
- Deciphering the adsorption machinery of Deep-Blue and Vp4, two myophages targeting members of theJournal of virology · 2024Article
- A multifaceted investigation of lactococcal strain diversity in undefined mesophilic starter cultures.Applied and environmental microbiology · 2024Article
- Ongoing shuffling of protein fragments diversifies core viral functions linked to interactions with bacterial hosts.Nature communications · 2023Article
- Article
- Exploring Host-Binding Machineries of Mycobacteriophages with AlphaFold2.Journal of virology · 2023Article
- Evolved distal tail protein of skunaviruses facilitates adsorption to exopolysaccharide-encoding lactococci.Microbiome research reports · 2023Article
- Exploring Structural Diversity among Adhesion Devices Encoded by Lactococcal P335 Phages with AlphaFold2.Microorganisms · 2022Article
- Viral Proteins Involved in the Adsorption Process of Deep-Purple, a Siphovirus Infecting Members of the Bacillus cereus Group.Applied and environmental microbiology · 2022Article
- Article
- Bacteriophage-host interactions as a platform to establish the role of phages in modulating the microbial composition of fermented foods.Microbiome research reports · 2022Review
- Host-encoded, cell surface-associated exopolysaccharide required for adsorption and infection by lactococcal P335 phage subtypes.Frontiers in microbiology · 2022Article
- A structural discovery journey of streptococcal phages adhesion devices by AlphaFold2.Frontiers in molecular biosciences · 2022Article
- Structure and Topology Prediction of Phage Adhesion Devices Using AlphaFold2: The Case of TwoMicroorganisms · 2021Article
- Reprogramming bacteriophage host range: design principles and strategies for engineering receptor binding proteins.Current opinion in biotechnology · 2021Review
- Genome Sequence and Characterization ofPHAGE (New Rochelle, N.Y.) · 2021Article
- Revisiting the host adhesion determinants of Streptococcus thermophilus siphophages.Microbial biotechnology · 2020Article
- Novel Genus of Phages Infecting Streptococcus thermophilus: Genomic and Morphological Characterization.Applied and environmental microbiology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
With the availability of an increasing number of 3D structures of bacteriophage components, combined with powerful in silico predictive tools, it has become possible to decipher the structural assembly and functionality of phage adhesion devices. In the current study, we examined 113 members of the 936 group of lactococcal siphophages, and identified a number of Carbohydrate Binding Modules (CBMs) in the neck passage structure and major tail protein, on top of evolved Dit proteins, as recently reported by us. The binding ability of such CBM-containing proteins was assessed through the construction of green fluorescent protein fusion proteins and subsequent binding assays. Two CBMs, one from the phage tail and another from the neck, demonstrated definite binding to their phage-specific host. Bioinformatic analysis of the structural proteins of 936 phages reveals that they incorporate binding modules which exhibit structural homology to those found in other lactococcal phage groups and beyond, indicating that phages utilize common structural "bricks" to enhance host binding capabilities. The omnipresence of CBMs in Siphophages supports their beneficial role in the infection process, as they can be combined in various ways to form appendages with different shapes and functionalities, ensuring their success in host detection in their respective ecological niches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.