Evidence map›Paper›PMID 31323976›Full record

ArticleCells2019

Arachidonic Acid Evokes an Increase in Intracellular Ca

Roberto Berra-Romani, Pawan Faris, Sharon Negri, Laura Botta, Tullio Genova, Francesco Moccia

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 41 citations in OpenAlex.

  1. The CaInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Exploring the effects ofFrontiers in pharmacology · 2025
    Article
  9. Article
  10. The Molecular Heterogeneity of Store-Operated CaInternational journal of molecular sciences · 2023
    Review
  11. Review
  12. GABACells · 2022
    Article
  13. Review
  14. Article
  15. Histamine activates an intracellular CaFrontiers in cell and developmental biology · 2022
    Article
  16. Reactive Oxygen Species and Endothelial CaInternational journal of molecular sciences · 2021
    Review
  17. Review
  18. The human amniotic fluid stem cell secretome triggers intracellular CaJournal of cellular and molecular medicine · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Roberto Berra-RomaniBiomedicine School, Benemerita Universidad Autonoma de Puebla, 72000 Puebla, Mexico.ORCID 0000-0003-4884-0925
Pawan FarisLaboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-6867-0359
Sharon NegriLaboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.
Laura BottaLaboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-5199-1383
Tullio GenovaDepartment of Life Sciences and Systems Biology, University of Torino, 10123 Torino, Italy.ORCID 0000-0001-7824-8389
Francesco MocciaLaboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. francesco.moccia@unipv.it.ORCID 0000-0003-0010-0098
University of Pavia · ITBenemérita Universidad Autónoma de Puebla · MXUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has long been known that the conditionally essential polyunsaturated arachidonic acid (AA) regulates cerebral blood flow (CBF) through its metabolites prostaglandin E2 and epoxyeicosatrienoic acid, which act on vascular smooth muscle cells and pericytes to vasorelax cerebral microvessels. However, AA may also elicit endothelial nitric oxide (NO) release through an increase in intracellular Ca

Indexed as

Calcium SignalingArachidonic AcidBrainCalciumCalcium ChannelsCells, CulturedEndothelial CellsEndothelium, VascularHumansInositol 1,4,5-Trisphosphate ReceptorsMicrocirculationNitric OxideTRPV Cation ChannelsArachidonic AcidCalciumCalcium ChannelsInositol 1,4,5-Trisphosphate ReceptorsNitric OxideTRPV Cation Channelsarachidonic acidbrain microvascular endothelial cellsCa2+ signallingcerebral blood flowinositol-1,4,5-trisphosphate receptorsneurovascular couplingnitric oxidetransient receptor potential vanilloid 4two-pore channels 1-2

Identifiers

PMID31323976
PMCPMC6678502
OpenAlexW2958630766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.