ReviewJournal of clinical medicine2019
Identification of Retinal Biomarkers in Alzheimer's Disease Using Optical Coherence Tomography: Recent Insights, Challenges, and Opportunities.
Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04153773 (Retinal Thickness as a Potential Biomarker of Neurodegeneration and Early Cognitive Impairment in Patients With Multiple Sclerosis), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Retinal Thickness as a Potential Biomarker of Neurodegeneration and Early Cognitive Impairment in Patients With Multiple Sclerosis
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Diagnosing neurodegenerative disorders using retina as an external window: A systematic review of OCT-MRI correlations.Journal of Alzheimer's disease : JAD · 2025Pooled it
- The Retinal Age Gap as a Marker of Accelerated Aging in the Early Course of Schizophrenia.Schizophrenia bulletin · 2026Article
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Article
- Non-invasiveFrontiers in cellular neuroscience · 2024Review
- Structural and Functional Retinal Changes in Patients with Mild Cognitive Impairment with and without Diabetes.Journal of clinical medicine · 2023Article
- Potential Ocular Biomarkers for Early Detection of Alzheimer's Disease and Their Roles in Artificial Intelligence Studies.Neurology and therapy · 2023Review
- Early visual alterations in individuals at-risk of Alzheimer's disease: a multidisciplinary approach.Alzheimer's research & therapy · 2023Article
- Schizophrenia in Translation: Why the Eye?Schizophrenia bulletin · 2022Article
- Intraretinal Layer Segmentation Using Cascaded Compressed U-Nets.Journal of imaging · 2022Article
- Ocular Vascular Changes: Choroidal Thickness as an Early Biomarker for Alzheimer's Disease?Journal of personalized medicine · 2021Article
- Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring.International journal of molecular sciences · 2021Review
- Retinal imaging in Alzheimer's and neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Review
- Ocular Vascular Changes in Mild Alzheimer's Disease Patients: Foveal Avascular Zone, Choroidal Thickness, and ONH Hemoglobin Analysis.Journal of personalized medicine · 2020Article
- A machine learning approach for retinal images analysis as an objective screening method for children with autism spectrum disorder.EClinicalMedicine · 2020Article
- Investigating Vascular Complexity and Neurogenic Alterations in Sectoral Regions of the Retina in Patients With Cognitive Impairment.Frontiers in physiology · 2020Article
- A recommended "minimum data set" framework for SD-OCT retinal image acquisition and analysis from the Atlas of Retinal Imaging in Alzheimer's Study (ARIAS).Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Optic Nerve Head Optical Coherence Tomography Angiography Findings after Coronavirus Disease.Journal of ophthalmic & vision researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
This review will highlight recent insights into measuring retinal structure in Alzheimer's disease (AD). A growing body of evidence indicates that disturbances in retinal blood flow and structure are related to cognitive function, which can severely impair vision. Optical coherence tomography (OCT) is an optical imaging technology that may allow researchers and physicians to gain deeper insights into retinal morphology and clarify the impact of AD on retinal health and function. Direct and noninvasive measurement of retinal morphology using OCT has provided useful diagnostic and therapeutic indications in several central nervous system (CNS) diseases, including AD, multiple sclerosis, and Parkinson disease. Despite several limitations, morphology assessment in the retinal layers is a significant advancement in the understanding of ocular diseases. Nevertheless, additional studies are required to validate the use of OCT in AD and its complications in the eye.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.