ArticleInternational journal of environmental research and public health2019
Children's DAT1 Polymorphism Moderates the Relationship Between Parents' Psychological Profiles, Children's DAT Methylation, and Their Emotional/Behavioral Functioning in a Normative Sample.
Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Cross-Tissue Specificity of Pediatric DNA Methylation Associated With Cumulative Family Stress.Developmental psychobiology · 2025Article
- Recent Developments in Eating Disorders in Children: A Comprehensive Perspective.Journal of clinical medicine · 2025Article
- Body dissatisfaction, drive for thinness, and psychopathological symptoms in preadolescents who use Instagram.Eating and weight disorders : EWD · 2025Article
- The Role of Parental and Adolescent Psychosocial Factors in Different Aggression Profiles: A Comparative Approach.Journal of clinical medicine · 2025Article
- Further Evidence on Online Video-Feedback Intervention: Enhancing Parent-Child Interactions and Reducing Disordered Eating in Children.International journal of environmental research and public health · 2024Article
- The Effects of Breastfeeding on Childhood Behavioral and Emotional Development: A Prospective Cohort Study in China.Nutrients · 2024Article
- Analysis of the Methylation Level of theInternational journal of molecular sciences · 2023Article
- Breastfeeding Apps: A Descriptive Report.Behavioral sciences (Basel, Switzerland) · 2023Article
- Epidemiology, Etiology and Intervention Strategies for Peri-Partum Depression in Mothers.Journal of clinical medicine · 2023Article
- The Relationship between Paternal Alexithymia and Children's Internalizing and Externalizing Behavioral Problems during Early Childhood.Children (Basel, Switzerland) · 2023Article
- Daring and Distress: Insights on Adolescent Risk Taking and Difficulties in Emotion Regulation from a Network Analysis Perspective.Brain sciences · 2023Article
- Implementing Sensitivity and Contingency in Medical Contexts: The Case of Prematurity.Journal of clinical medicine · 2023Article
- Personalized Psychological Interventions in Children: Harnessing Advancements in Genetic and Epigenetic Research.Journal of clinical medicine · 2023Article
- What Is Going on with Childhood?Behavioral sciences (Basel, Switzerland) · 2023Article
- Parent-Child Separation Always Comes with a Cost.European journal of investigation in health, psychology and education · 2023Article
- Epigenetic Analysis of the Dopamine Transporter GeneInternational journal of molecular sciences · 2023Article
- Methylation in the Promoter Region of the Dopamine TransporterInternational journal of environmental research and public health · 2022Article
- Adolescent Attachment to Parents and Peers and the Use of Instagram: The Mediation Role of Psychopathological Risk.International journal of environmental research and public health · 2021Article
- DNA Methylation and Allelic Polymorphism at the Dopamine Transporter Promoter Affect Internalizing and Externalizing Symptoms in Preschoolers.Child psychiatry and human development · 2021Article
- DAT1 and Its Psychological Correlates in Children with Avoidant/Restrictive Food Intake Disorder: A Cross-Sectional Pilot Study.Behavioral sciences (Basel, Switzerland) · 2021Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parental psychopathological risk is considered as one of the most crucial features associated with epigenetic modifications in offspring, which in turn are thought to be related to their emotional/behavioral profiles. The dopamine active transporter (DAT) gene is suggested to play a significant role in affective/behavioral regulation. On the basis of the previous literature, we aimed at verifying whether children's DAT1 polymorphisms moderated the relationship between parents' psychological profiles, children's emotional/behavioral functioning, and DAT1 methylation in a normative sample of 79 families with school-age children (Ntot = 237). Children's biological samples were collected through buccal swabs, while Symptom Check-List-90 item Revised, Adult Self Report, and Child Behavior Check-List/6-18 was administered to assess parental and children's psychological functioning. We found that higher maternal externalizing problems predicted the following: higher levels of children's DAT1 methylation at M1, but only among children with 10/10 genotype; higher levels of methylation at M2 among children with 10/10 genotype; while lower levels for children with a 9-repeat allele. There was also a positive relationship between fathers' externalizing problems and children's externalizing problems, only for children with a 9-repeat allele. Our findings support emerging evidence of the complex interplay between genetic and environmental factors in shaping children' emotional/behavioral functioning, contributing to the knowledge of risk variables for a child's development and psychological well-being.
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