Evidence map›Paper›PMID 31323757›Full record

ReviewCells2019

Mathematical Modeling of Mucociliary Clearance: A Mini-Review.

Ling Xu, Yi Jiang

Abstract readReview
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ling XuDepartment of Mathematics, North Carolina A & T State University, Greensboro, NC 27411, USA. lxu@ncat.edu.
Yi JiangDepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA. yjiang12@gsu.edu.

Funding

P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI NICKERSON, JOHN M · 1986 to 2025
$15.3M
VIsion Science Training in AtlantaT32EY007092 · NEI · EMORY UNIVERSITY · PI Machelle T. Pardue · 1985 to 2026
$4.6M
Ocular Growth, Emmetropia, and Interphotoreceptor Retinoid-Binding Protein (IRBP)R01EY021592 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H, IUVONE, P MICHAEL · 2013 to 2021
$3.3M
The RPE and Recovery of the Blood Retina BarrierR01EY028450 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H, GROSSNIKLAUS, HANS E. · 2018 to 2022
$2.4M
Defining Early Escape Strategies in LKB1 Mutant Lung Cancer S1R01CA201340 · NCI · EMORY UNIVERSITY · PI GILBERT-ROSS, MELISSA, MARCUS, ADAM I. · 2016 to 2020
$2.0M
Exercise-induced Retinal NeuroprotectionR01EY028859 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H, PARDUE, MACHELLE T. · 2018 to 2021
$2.0M
NCI NIH HHS R01 CA201340NEI NIH HHS P30 EY006360NEI NIH HHS R01 EY021592NEI NIH HHS R01 EY028450
6 · The paper itself

Abstract

Mucociliary clearance is an important innate host defense of the mammalian respiratory system, as it traps foreign substances, including pollutants, pathogens, and allergens, and transports them out of the airway. The underlying mechanism of the actuation and coordination of cilia, the interplay between the cilia and mucus, and the formation of the metachronal wave have been explored extensively both experimentally and mathematically. In this mini-review, we provide a survey of the mathematical models of mucociliary clearance, from the motion of one single cilium to the emergence of the metachronal wave in a group of them, from the fundamental theoretical study to the state-of-the-art three-dimensional simulations. The mechanism of cilium actuation is discussed, together with the mathematical simplification and the implications or caveats of the results.

Indexed as

Models, TheoreticalMucociliary ClearanceAnimalsCiliaHumansRespiratory Mucosaciliaclearancemathematical modelingmucus

Identifiers

PMID31323757
PMCPMC6678682

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.