ArticleInvestigative ophthalmology & visual science2019
Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma.
Article in Investigative ophthalmology & visual science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Diagnostic performance of laser speckle flowgraphy in glaucoma: a systematic review and meta-analysis.International ophthalmology · 2021Pooled it
- Changes in ocular blood flow and haemodynamic waveform parameters following trabeculectomy.BMJ open ophthalmology · 2026Article
- Extravascular Motion Signal Detected by OCT Angiography Indicates Altered Vascular-Tissue Biomechanical Interactions in Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Relations Between Pulsatility in the Optic Nerve Head or Peripapillary Retinal Vessels and the Rate of Progression in Glaucoma.Investigative ophthalmology & visual science · 2025Article
- Changes in vascular resistance with intraocular pressure and damage severity in experimental glaucoma.Experimental eye research · 2025Article
- Challenging glaucoma with emerging therapies: an overview of advancements against the silent thief of sight.Frontiers in medicine · 2025Review
- Factors Associated With Ocular Perfusion Measurements as Obtained With Laser Speckle Contrast Imaging.Translational vision science & technology · 2024Article
- Vascular resistance indices are higher in the superior than inferior optic nerve head and retina.Experimental eye research · 2024Article
- Assessment of Time Lag Between Blood Flow, Retinal Nerve Fiber Layer Thickness and Visual Field Sensitivity Changes in Glaucoma.Investigative ophthalmology & visual science · 2024Article
- Retinal Vessel Pulsatile Characteristics Associated With Vascular Stiffness Can Predict the Rate of Functional Progression in Glaucoma Suspects.Investigative ophthalmology & visual science · 2023Article
- Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma.International journal of molecular sciences · 2022Article
- Characteristics of laterality in the optic nerve head microcirculation obtained by laser speckle flowgraphy in healthy subjects.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Longer Axial Length Potentiates Relationship of Intraocular Pressure and Peripapillary Vessel Density in Glaucoma Patients.Investigative ophthalmology & visual science · 2021Article
- Vascular Aspects in Glaucoma: From Pathogenesis to Therapeutic Approaches.International journal of molecular sciences · 2021Review
- Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation.Scientific reports · 2021Article
- Ocular and Systemic Factors Affecting Laser Speckle Flowgraphy Measurements in the Optic Nerve Head.Translational vision science & technology · 2021Article
- Ocular blood flow as a clinical observation: Value, limitations and data analysis.Progress in retinal and eye research · 2020Article
- Dynamic Alterations in Blood Flow in Glaucoma Measured with Laser Speckle Contrast Imaging.Ophthalmology. GlaucomaObservational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Purpose: Blood flow in the optic nerve head (ONH) is known to be reduced in eyes with advanced glaucoma. However, experimental results from non-human primates suggest an initial increase in ONH blood flow at the earliest stages of damage. This study assesses flow and pulsatile hemodynamics across a range of severities to test the hypothesis that this also occurs in human glaucoma. Methods: Laser speckle flowgraphy was used to measure average mean blur rate (MBRave) within ONH tissue (a correlate of capillary blood flow) and the pulsatile waveform in 93 eyes with functional loss and 74 glaucoma suspect/fellow eyes without functional loss. These were compared against results from 92 healthy control eyes. Parameters produced by the instrument's software were age-corrected, then compared between groups using generalized estimating equation models. Results: The mean MBRave in the control eyes was 12.5 units. In glaucoma suspect/fellow eyes, the mean was 16.4 units, higher with P < 0.0001. In eyes with functional loss, the mean was 13.8 units, lower than eyes without functional loss with P < 0.0001, although still higher than control eyes with P = 0.0096. Analysis of the pulsatile waveform suggested that the deceleration in flow as it approaches its maximum across the cardiac cycle was delayed in glaucoma. Conclusions: Blood flow within ONH capillaries was higher in glaucoma suspect eyes than in healthy controls. It was less elevated in eyes that had developed functional loss. The mechanisms causing these changes and their relation to concurrent changes in pulsatile hemodynamics remain under investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.