ArticleRheumatology (Oxford, England)2019
Interhospital variation in mortality among patients with systemic lupus erythematosus and sepsis in the USA.
Article in Rheumatology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Mendelian randomization study of the causal relationship between autoimmune diseases and anemia using proteomic and genetic data.Journal of translational autoimmunity · 2025Article
- Trust performance in managing inflammatory arthritis over time in England and Wales: a latent class analysis approach.Rheumatology advances in practice · 2024Article
- Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study.Critical care (London, England) · 2023Observational
- Improving patient pathways for systemic lupus erythematosus: a multistakeholder pathway optimisation study.Lupus science & medicine · 2022Article
- Antimalarial treatment and minimizing prednisolone are associated with lower risk of infection in SLE: a 24-month prospective cohort study.Clinical rheumatology · 2022Article
- Sepsis Mortality Is high in Patients With Connective Tissue Diseases Admitted to the Intensive Care Unit (ICU).Journal of intensive care medicine · 2022Article
- Article
- Impact of systemic lupus erythematosus on the 5-year survival of critically ill septic patients.Arthritis research & therapy · 2021Article
- Long-term outcomes in systemic lupus erythematosus: trends over time and major contributors.Rheumatology (Oxford, England) · 2020Review
- Use of Quality Measures to Identify Disparities in Health Care for Systemic Lupus Erythematosus.Rheumatic diseases clinics of North America · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveTo determine whether the risk of mortality in patients with SLE hospitalized with sepsis varies among hospitals in the USA.
methodsWe used the National Inpatient Sample (2002-2011) to obtain national population-based data on outcomes for adults with SLE admitted with sepsis, and compared it with that for patients without SLE admitted with sepsis at the same hospital. We computed expected mortality based on patient demographic characteristics, comorbidities and major organ dysfunction, and calculated observed/expected (O/E) mortality ratios separately for patients with SLE and without SLE for each hospital. We then computed the ratio of these O/E ratios within hospitals to assess relative SLE mortality. We considered hospitals with a risk ratio (RR) of ⩾2.0 as having high relative SLE mortality.
resultsAmong 424 hospitals that treated a total of 4024 patients with SLE and sepsis, the risk of in-hospital mortality varied from 0% to 60% (median 11.1%). The RR ranged from 0 to 9.75, with a median of 0.84, indicating that O/E mortality was similar in patients with and without SLE at the average hospital. Sixty-one hospitals (14.4%) had a RR of ⩾2.0, indicating higher mortality among patients with SLE. Hospitals that on average treated ⩾3.9 patients with SLE and sepsis annually were less likely to have a RR of ⩾2.0 than hospitals that treated fewer patients (10% vs 17%; P = 0.004).
conclusionMortality among patients with SLE and sepsis varied widely between hospitals, and was lower at hospitals that treated more of these patients.
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