ArticleJournal of controlled release : official journal of the Controlled Release Society2019
Noninvasive characterization of in situ forming implant diffusivity using diffusion-weighted MRI.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Impact of Mixing Approach and Bubble Formation on In Situ Forming Implant Properties.Pharmaceutical research · 2026Article
- In vitro and in vivo evaluation of in situ forming polyester implants for the extended release of carvedilol.Drug delivery and translational research · 2025Article
- An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation.Theranostics · 2024Article
- Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Basic Salt Additives Modulate the Acidic Microenvironment Around In Situ Forming Implants.Annals of biomedical engineering · 2023Article
- Article
- A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis.Nature communications · 2022Article
- Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics.Pharmaceutics · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In situ forming implants (ISFIs) form a solid drug-eluting depot, releasing drug for an extended period of time after a minimally-invasive injection. Clinical use of ISFIs has been limited because many factors affect drug release kinetics. The aim of this study was to use diffusion-weighted MRI (DWI) to noninvasively quantify spatial-temporal changes in implant diffusivity in situ. ISFIs were formed using poly(lactic-co-glycolic) acid, with a molecular weight of either 15 kDa or 52 kDa, and fluorescein as the mock drug. Drug release, polymer erosion, polymer degradation, and implant diffusivity were analyzed in vitro over 21 days. DWI was also performed in vivo over 5 days. Spatial diffusivity maps of the implant were generated using DWI data. Results showed constant diffusivity at the implant shell ((1.17 ± 0.13) × 10
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Registered trials
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