ArticleAmerican journal of ophthalmology2019
Quantification of Choriocapillaris with Optical Coherence Tomography Angiography: A Comparison Study.
Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- OCTA measurements in Behcet's disease across different stages of the disease activity: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Automated optical coherence tomography quantification of retinal wall-to-lumen alterations in preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Exploring the Maximum Detectable Percentage of Choriocapillaris Flow Deficits Within Geographic Atrophy Using SS-OCT Angiography.Investigative ophthalmology & visual science · 2026Article
- Simple 3D-printed stirred bioreactor enhances retinal organoid production via improved oxygenation.Cell reports methods · 2026Article
- Impact of Swept-Source OCT Angiographic Scanning Speeds on the Detection of Choriocapillaris Flow Deficits in Eyes With AMD.Translational vision science & technology · 2026Article
- Hyporeflective Core Drusen Cause an Artifactual Bending of Bruch's Membrane on OCT Images: Optical Mechanism and Proposed Quantitative Metrics.Investigative ophthalmology & visual science · 2026Observational
- Choriocapillaris Flow Deficits Are Spatially Linked to Retinal Pigment Epithelium and Photoreceptor Integrity in Geographic Atrophy.Investigative ophthalmology & visual science · 2026Article
- Quantitative evaluation of the topographical maps of three-dimensional choroidal vascularity index in gestational diabetes mellitus: a cross-sectional observational study.BMC pregnancy and childbirth · 2026Observational
- Changes in Choriocapillaris Flow Deficits Before and After the Onset of Large Choroidal Hypertransmission Defects in AMD.Investigative ophthalmology & visual science · 2025Article
- Quantification of Normative Human Choriocapillaris Measures Across the Macula.Investigative ophthalmology & visual science · 2025Article
- Quantifying Choriocapillaris Flow Deficits in Diabetic Retinopathy Using Projection-Resolved OCT Angiography.Investigative ophthalmology & visual science · 2025Article
- Comparison of choriocapillaris perfusion between swept-source optical coherence tomography angiography and spectral-domain optical coherence tomography angiography in five different choriocapillaris slabs in patients with intermediate age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Simple 3D-Printed Stirred Bioreactor Enhances Retinal Organoid Production Via Improved Oxygenation.bioRxiv : the preprint server for biology · 2025Article
- Flow and ischemic changes in retina and choroid across diabetic retinopathy spectrum: a SS-OCTA study.Eye (London, England) · 2025Observational
- A Novel Grid Strategy for Correlating Focal Macular Anatomic Changes With Focal Changes in Choriocapillaris Perfusion.Investigative ophthalmology & visual science · 2024Article
- Evaluation of Retinal and Posterior Segment Vascular Changes Due to Systemic Hypoxia Using Optical Coherence Tomography Angiography.Journal of clinical medicine · 2024Article
- Factors Affecting Disease Stability After Intravitreal Brolucizumab Injection for Refractory Neovascular Age-Related Macular Degeneration.Ophthalmology and therapy · 2024Article
- Calcified Drusen Prevent the Detection of Underlying Choriocapillaris Using Swept-Source Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2024Article
- Retinal Vessel Analysis and Microvascular Abnormalities in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms.Journal of clinical medicine · 2024Article
- Impact of slab selection on the relationship between choriocapillaris flow deficits and enlargement rate of geographic atrophy.Eye (London, England) · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeTo demonstrate the variation in quantitative choriocapillaris (CC) metrics with various binarization approaches using optical coherence tomography angiography (OCTA).
designRetrospective, observational, cross-sectional case series.
methodsMacular OCTA scans, 3- × 3-mm and 6- × 6-mm, were obtained from normal eyes and from eyes with drusen secondary to age-related macular degeneration (AMD). The CC slab was extracted, and the CC flow deficits (FDs) were segmented with 2 previously published algorithms: the fuzzy C-means approach (FCM method) and Phansalkar's local thresholding (Phansalkar method). Four different values for the radius were used in order to investigate the effect on the FD segmentation when using the Phansalkar method. FD density (FDD), mean FD size (MFDS), FD number (FDN), FD area (FDA) and intercapillary distance (ICD) were calculated for comparison. Repeatability was assessed as coefficient of variation (CV), and Pearson's correlation analysis was conducted.
resultsSix eyes from 6 subjects with normal eyes and 6 eyes from 6 subjects with drusen secondary to AMD were scanned. The 3- × 3-mm scans resulted in higher repeatability than the 6- × 6-mm scans. For the Phansalkar method, larger values of the radius resulted in higher repeatability. ANOVA tests resulted in significant differences (P < 0.001) among the FCM method and the Phansalkar method with different radius options for all CC metrics and scan sizes investigated. In 3- × 3-mm scans, significant correlation was found between the FCM method and the Phansalkar method for all quantitative CC metrics other than FDN (all P < 0.001; 0.90 < r <0.99).
conclusionsQuantitative CC analysis with commercially available OCTA is complicated and researchers need to pay close attention to how they conduct such analyses.
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