ArticlePLoS pathogens2019
Peer pressure from a Proteus mirabilis self-recognition system controls participation in cooperative swarm motility.
Article in PLoS pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Genomic profiling ofMicrobiology spectrum · 2026Article
- Regulated cell death in fungi from a comparative immunology perspective.Cell death and differentiation · 2026Review
- Article
- Genetic Basis of Gap Formation Between MigratingMicroorganisms · 2025Article
- Two reasons to kill: predation and kin discrimination in myxobacteria.Microbiology (Reading, England) · 2023Review
- Review
- Article
- Surveying a Swarm: Experimental Techniques To Establish and Examine Bacterial Collective Motion.Applied and environmental microbiology · 2022Article
- The Conserved Serine Transporter SdaC Moonlights To Enable Self Recognition.Journal of bacteriology · 2022Article
- Into the understanding the multicellular lifestyle ofFrontiers in cellular and infection microbiology · 2022Review
- Loss of Motility as a Non-Lethal Mechanism for Intercolony Inhibition ("Sibling Rivalry") inMicroorganisms · 2021Article
- Coaggregation properties of trimeric autotransporter adhesins.MicrobiologyOpen · 2020Article
- Growth Recovery Assay and FACS-based Population Sorting Following Territorial Exclusion inBio-protocol · 2020Article
- Pathogenic Factors Correlate With Antimicrobial Resistance Among ClinicalFrontiers in microbiology · 2020Article
- Biofilms 2018: A diversity of microbes and mechanisms.Journal of bacteriology · 2019Review
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colonies of the opportunistic pathogen Proteus mirabilis can distinguish self from non-self: in swarming colonies of two different strains, one strain excludes the other from the expanding colony edge. Predominant models characterize bacterial kin discrimination as immediate antagonism towards non-kin cells, typically through delivery of toxin effector molecules from one cell into its neighbor. Upon effector delivery, receiving cells must either neutralize it by presenting a cognate anti-toxin as would a clonal sibling, or suffer cell death or irreversible growth inhibition as would a non-kin cell. Here we expand this paradigm to explain the non-lethal Ids self-recognition system, which stops access to a social behavior in P. mirabilis by selectively and transiently inducing non-self cells into a growth-arrested lifestyle incompatible with cooperative swarming. This state is characterized by reduced expression of genes associated with protein synthesis, virulence, and motility, and also causes non-self cells to tolerate previously lethal concentrations of antibiotics. We show that temporary activation of the stringent response is necessary for entry into this state, ultimately resulting in the iterative exclusion of non-self cells as a swarm colony migrates outwards. These data clarify the intricate connection between non-lethal recognition and the lifecycle of P. mirabilis swarm colonies.
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