ArticlePLoS genetics2019
DAF-16/FOXO promotes taste avoidance learning independently of axonal insulin-like signaling.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 37 citations in OpenAlex.
- Proximity Labeling inBio-protocol · 2026Article
- Synaptic proteomics identifies cathepsin B as a regulator of synapse remodelling during learning.bioRxiv : the preprint server for biology · 2026Article
- Metabolic state modulates risky foraging behavior via multiple branches of the insulin/IGF-1-like pathway in C. elegans.G3 (Bethesda, Md.) · 2026Article
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- Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning.Cell genomics · 2024Article
- Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans.Scientific reports · 2024Article
- Behavioral Tests for Associative Learning in Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.) · 2024Article
- FOXO inBiology · 2023Article
- Multiple p38/JNK mitogen-activated protein kinase (MAPK) signaling pathways mediate salt chemotaxis learning in C. elegans.G3 (Bethesda, Md.) · 2023Article
- Article
- Uncovering novel regulators of memory using C. elegans genetic and genomic analysis.Biochemical Society transactions · 2023Review
- Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO inFoods (Basel, Switzerland) · 2022Article
- Involvement of HECT-type E3 ubiquitin ligase genes in salt chemotaxis learning in Caenorhabditis elegans.Genetics · 2022Article
- DAF-2c signaling promotes taste avoidance after starvation in Caenorhabditis elegans by controlling distinct phospholipase C isozymes.Communications biology · 2022Article
- Insulin and Memory in Invertebrates.Frontiers in behavioral neuroscience · 2022Review
- Pioglitazone Hydrochloride Extends the Lifespan ofOxidative medicine and cellular longevity · 2022Article
- Review
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- The phosphatidylinositol transfer protein PITP-1 facilitates fast recovery of eating behavior after hypoxia in the nematode Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Transcription Factors That Control Behavior-Lessons FromFrontiers in neuroscience · 2021Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The avoidance of starvation is critical for the survival of most organisms, thus animals change behavior based on past nutritional conditions. Insulin signaling is important for nutritional state-dependent behavioral plasticity, yet the underlying regulatory mechanism at the cellular level remains unclear. Previous studies showed that insulin-like signaling is required for taste avoidance learning, in which the nematode Caenorhabditis elegans avoids salt concentrations encountered under starvation conditions. DAF-2c, a splice isoform of the DAF-2 insulin receptor, functions in the axon of the ASER sensory neuron, which senses changes in salt concentrations. In addition, mutants of a major downstream factor of DAF-2, the forkhead transcription factor O (FOXO) homolog DAF-16, show defects in taste avoidance learning. Interestingly, the defect of the daf-2 mutant is not suppressed by daf-16 mutations in the learning, unlike those in other phenomena, such as longevity and development. Here we show that multiple DAF-16 isoforms function in ASER. By epistasis analysis using a DAF-2c isoform-specific mutant and an activated form of DAF-16, we found that DAF-16 acts in the nucleus in parallel with the DAF-2c-dependent pathway in the axon, indicating that insulin-like signaling acts both in the cell body and axon of a single neuron, ASER. Starvation conditioning induces nuclear translocation of DAF-16 in ASER and degradation of DAF-16 before starvation conditioning causes defects in taste avoidance learning. Forced nuclear localization of DAF-16 in ASER biased chemotaxis towards lower salt concentrtions and this effect required the Gq/PKC pathway and neuropeptide processing enzymes. These data imply that DAF-16/FOXO transmits starvation signals and modulates neuropeptide transmission in the learning.
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